{"id":"W4405414128","doi":"10.1016/j.ocarto.2024.100558","title":"Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis","year":2024,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage Open","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Dr Trygve Gythfeldt og Frues Forskningsfond; Helse Sør-Øst RHF; Diakonhjemmet; Olav Thon Stiftelsen; Anders Jahres Fond til Vitenskapens Fremme; Norges Forskningsråd","keywords":"Osteoarthritis; Placebo; Protocol (science); Randomized controlled trial; Medicine; Physical therapy; Methotrexate; Internal medicine; Alternative medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02527084,0.006654051,0.009707872,0.001905757,0.004154768,0.003920207,0.003467811,0.009357344,0.1164732],"category_scores_gemma":[0.02541721,0.002676839,0.003746805,0.002297431,0.003963627,0.004602537,0.001813845,0.01090069,0.02928829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00303228,"about_ca_system_score_gemma":0.01325847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001124466,"about_ca_topic_score_gemma":0.002905113,"domain_scores_codex":[0.9790702,0.01244885,0.00196148,0.002550248,0.002375168,0.001594014],"domain_scores_gemma":[0.9897174,0.002073437,0.002189474,0.001624655,0.002303703,0.002091361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8774101,0.008871897,0.0008371206,0.01633916,0.001152955,0.0003444916,0.0003831289,0.0009895934,0.002326735,0.006044468,0.05265224,0.03264816],"study_design_scores_gemma":[0.9010457,0.01665192,0.001433226,0.002677225,0.00050926,0.00009725062,0.00007323451,0.0009948397,0.000624053,0.002153979,0.07363564,0.0001036976],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.001358493,0.0004802664,0.001180986,0.0003094427,0.0006932596,0.9921163,0.001969615,0.0001568583,0.001734789],"genre_scores_gemma":[0.001881348,0.0001966184,0.001308301,0.000433746,0.0001283561,0.9946315,0.0004351982,0.0000113631,0.0009735975],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.1164732,"threshold_uncertainty_score":0.3896415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02721816457037464,"score_gpt":0.3641501766131994,"score_spread":0.3369320120428247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}