{"id":"W4405416445","doi":"10.69598/sehs.18.24050018","title":"Forward selection models for classifying mild cognitive impairment and Alzheimer’s disease based on single nucleotide polymorphisms","year":2024,"lang":"en","type":"article","venue":"Science, Engineering and Health Studies","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Janssen Alzheimer Immunotherapy Research And Development; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Alzheimer's Association","keywords":"Single-nucleotide polymorphism; Selection (genetic algorithm); Cognitive impairment; Disease; Cognition; Alzheimer's disease; Medicine; Genetics; Computational biology; Neuroscience; Biology; Computer science; Artificial intelligence; Internal medicine; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01297106,0.002328983,0.002007572,0.002653345,0.001056996,0.001509222,0.001991824,0.001595362,0.00166599],"category_scores_gemma":[0.01058859,0.0006118407,0.002900793,0.001267004,0.0007579293,0.0009741538,0.001076982,0.002687227,0.0007991247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009616553,"about_ca_system_score_gemma":0.002017255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01624045,"about_ca_topic_score_gemma":0.01473316,"domain_scores_codex":[0.9967684,0.001881092,0.0002143159,0.000495471,0.0003867498,0.0002539311],"domain_scores_gemma":[0.9923717,0.005633245,0.0004028756,0.0002809072,0.001119167,0.000192183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0017968,0.001115537,0.1233063,0.0003008468,0.002050356,0.0008356684,0.000519626,0.5309064,0.003595792,0.00614545,0.007269291,0.3221578],"study_design_scores_gemma":[0.00005678956,0.0001814845,0.004222954,0.00003049662,0.0001738294,0.0000727528,0.0000438246,0.9905703,0.0004771427,0.003634367,0.0005074508,0.00002857618],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2668148,0.003464624,0.7210779,0.002655562,0.0005503644,0.000669415,0.001437303,0.001305039,0.002025012],"genre_scores_gemma":[0.8872587,0.00109193,0.1029312,0.0007501864,0.00040762,0.0006699104,0.00238992,0.00007191813,0.004428528],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01624045,"threshold_uncertainty_score":0.06859833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06160764249012888,"score_gpt":0.3181576278414663,"score_spread":0.2565499853513374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}