{"id":"W4405430345","doi":"10.1016/j.biomaterials.2024.123032","title":"PPS-TLR7/8 agonist nanoparticles equip robust anticancer immunity by selectively prolonged activation of dendritic cells","year":2024,"lang":"en","type":"article","venue":"Biomaterials","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Shenyang Pharmaceutical University; National Natural Science Foundation of China","keywords":"TLR7; Agonist; Materials science; Nanoparticle; Immunity; Dendritic cell; Pharmacology; Nanotechnology; Cancer research; Biophysics; Immune system; Innate immune system; Receptor; Immunology; Medicine; Biology; Toll-like receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596365,0.0003923792,0.0002266309,0.0001629216,0.0001074812,0.0003160661,0.0001094151,0.0003645479,0.00169926],"category_scores_gemma":[0.0001401618,0.000134268,0.0001904923,0.00008147192,0.0001432466,0.0002416267,0.0002193354,0.0006370504,0.0006627394],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681656,"about_ca_system_score_gemma":0.0001704443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007012208,"about_ca_topic_score_gemma":0.00015441,"domain_scores_codex":[0.999809,0.00003588799,0.00001224951,0.00003201785,0.00004790753,0.00006292187],"domain_scores_gemma":[0.9999278,0.00001976895,0.00001813624,0.00001025584,0.00001059349,0.00001351014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001364703,0.00004111419,0.00004806617,0.00003612615,0.000003128553,0.00001886665,0.000007376938,0.00007983195,0.9976321,0.00009833872,0.00007897369,0.001819604],"study_design_scores_gemma":[0.00001269339,0.0003951157,0.0003881289,0.000004747017,0.00001006282,0.00008138696,0.00001179692,0.0004475527,0.9968869,0.00004241567,0.001716795,0.000002281298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865368,0.002104574,0.007272728,0.0001837522,0.0001354444,0.00008546398,0.0001819759,0.000176292,0.00332286],"genre_scores_gemma":[0.994347,0.0005631328,0.002402273,0.00009299319,0.00002582983,0.00006305702,0.0001426718,0.00002477335,0.002338258],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169926,"threshold_uncertainty_score":0.005684614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01891030470227351,"score_gpt":0.2578684582119827,"score_spread":0.2389581535097092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}