{"id":"W4405430896","doi":"10.22541/au.173438285.52591085/v1","title":"An AOP-informed testing strategy to identify chemicals causing genotoxicity through oxidative DNA damage: case study on 4-nitroquinoline 1-oxide","year":2024,"lang":"en","type":"preprint","venue":"","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"","keywords":"Genotoxicity; Oxidative damage; DNA damage; 4-Nitroquinoline 1-oxide; Chemistry; DNA; Oxidative stress; Business; Biochemistry; Toxicity; Carcinogenesis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003613791,0.0006257449,0.0007495683,0.001190162,0.0009042288,0.0008660804,0.001071953,0.001980143,0.001034687],"category_scores_gemma":[0.003552921,0.0003240074,0.0009836162,0.0005642507,0.0009667063,0.000651929,0.001068862,0.0009681198,0.000296079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009906791,"about_ca_system_score_gemma":0.0009349189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002812502,"about_ca_topic_score_gemma":0.006443745,"domain_scores_codex":[0.9978142,0.0006285789,0.0001240538,0.000343568,0.0009589699,0.0001305865],"domain_scores_gemma":[0.9977851,0.0008139556,0.0003785205,0.0002069786,0.000670946,0.0001445017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001107744,0.001886832,0.06497414,0.001279749,0.0001593179,0.0269831,0.002461536,0.01772986,0.7375542,0.003653292,0.00146699,0.1407433],"study_design_scores_gemma":[0.00008997665,0.0106094,0.02550848,0.000167199,0.0003065048,0.0216595,0.002039138,0.03399291,0.8795038,0.004066119,0.0218954,0.0001615795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8918357,0.001834773,0.09557521,0.002076141,0.00007811392,0.001628142,0.0005940098,0.0003475339,0.006030411],"genre_scores_gemma":[0.8584622,0.001802972,0.1322725,0.0006488694,0.0000455697,0.0003346859,0.0003002438,0.00007137992,0.006061645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003613791,"threshold_uncertainty_score":0.01911175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09640869028345564,"score_gpt":0.4333749077431911,"score_spread":0.3369662174597354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}