{"id":"W4405441258","doi":"10.1021/jacs.4c13558","title":"Photoswitchable Diazocine Derivative for Adenosine A<sub>3</sub> Receptor Activation in Psoriasis","year":2024,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NextGenerationEU; Faculty of Medicine and Health, University of Sydney; National Institutes of Health; Generalitat de Catalunya; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Centres de Recerca de Catalunya; Universitat Autònoma de Barcelona; Universitat de Barcelona; University of Pennsylvania; York University; Ministerio de Ciencia, Innovación y Universidades","keywords":"Chemistry; Agonist; Photoswitch; In vivo; Moiety; Adenosine; Biophysics; Receptor; In vitro; Derivative (finance); Stereochemistry; Biochemistry; Photochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006648147,0.000137927,0.0001061413,0.00008412325,0.00009364065,0.0001309223,0.0001651295,0.0001960662,0.0009653185],"category_scores_gemma":[0.00006580902,0.0000907143,0.0001079156,0.00006801401,0.0001584619,0.0001409836,0.0001268984,0.0002918922,0.0001807751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002083208,"about_ca_system_score_gemma":0.0001029241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003951129,"about_ca_topic_score_gemma":0.0006680523,"domain_scores_codex":[0.9999623,0.000005398578,0.000001607774,0.00001004845,0.00001184618,0.000008918355],"domain_scores_gemma":[0.9999727,0.000007241828,0.000008623784,0.000002825499,0.000003008887,0.000005620698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001364572,0.000005433197,0.00001367922,0.000009119682,7.28386e-7,0.0000200609,0.000003288397,0.00004839984,0.9991404,0.00007975965,0.00001538639,0.0006499648],"study_design_scores_gemma":[0.000004111436,0.00006233509,0.0002597416,8.451431e-7,0.000001969275,0.00005600159,0.000003690687,0.0004900871,0.9984383,0.00002077114,0.0006600925,0.000001994732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811384,0.001166817,0.01417082,0.0001159499,0.00003472986,0.00004595538,0.00007972991,0.0001333354,0.003114314],"genre_scores_gemma":[0.9921287,0.0005358984,0.005154749,0.00003764083,0.000005122544,0.00002731756,0.00004551731,0.00001568904,0.002049356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009653185,"threshold_uncertainty_score":0.00322932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087570068151305,"score_gpt":0.2531176378600766,"score_spread":0.2422419371785635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}