{"id":"W4405441258","doi":"10.1021/jacs.4c13558","title":"Photoswitchable Diazocine Derivative for Adenosine A<sub>3</sub> Receptor Activation in Psoriasis","year":2024,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Photochromic and Fluorescence Chemistry","field":"Materials Science","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NextGenerationEU; Faculty of Medicine and Health, University of Sydney; National Institutes of Health; Generalitat de Catalunya; European Commission; National Institute of Diabetes and Digestive and Kidney Diseases; Centres de Recerca de Catalunya; Universitat Autònoma de Barcelona; Universitat de Barcelona; University of Pennsylvania; York University; Ministerio de Ciencia, Innovación y Universidades","keywords":"Chemistry; Agonist; Photoswitch; In vivo; Moiety; Adenosine; Biophysics; Receptor; In vitro; Derivative (finance); Stereochemistry; Biochemistry; Photochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004152997,0.000142909,0.000331124,0.00001828714,0.00006017412,0.00005418826,0.0003733045,0.0000657823,0.00003544994],"category_scores_gemma":[0.0002890763,0.00009488875,0.0003474394,0.0004376323,0.0002874855,0.0002057441,0.00007837042,0.0003340511,0.000004735693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004332915,"about_ca_system_score_gemma":0.0001728713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001754016,"about_ca_topic_score_gemma":2.527166e-7,"domain_scores_codex":[0.9988337,0.00002640927,0.0003993724,0.0001987974,0.000281129,0.0002605893],"domain_scores_gemma":[0.9990021,0.0002867063,0.0003824572,0.0001455121,0.0001081645,0.00007506705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001161535,0.00005686763,0.00007916174,0.00005771082,0.00002888282,4.215467e-7,0.0005697139,0.000008675906,0.9798067,0.000005643776,0.01840525,0.0008647951],"study_design_scores_gemma":[0.0003522521,0.00004664127,0.0001735796,0.0002494178,0.00002518611,0.00000780633,0.0004939131,0.0002641048,0.9973554,0.0004073145,0.0005072077,0.0001172015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99628,0.0000838581,0.00117054,0.001983793,0.0002638246,0.0001623259,0.00001814616,0.000019154,0.0000183896],"genre_scores_gemma":[0.9957865,0.00009116431,0.003053062,0.0004751134,0.0005300744,0.00002361344,0.000002560565,0.00002005478,0.00001789092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01789804,"threshold_uncertainty_score":0.3869451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01087570068151305,"score_gpt":0.2531176378600766,"score_spread":0.2422419371785635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}