{"id":"W4405443547","doi":"10.1016/j.neuron.2024.11.006","title":"Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis","year":2024,"lang":"en","type":"article","venue":"Neuron","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Noble Research Institute; National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Nunavut Research Institute; National Institutes of Health; Texas Children's Hospital; International Rett Syndrome Foundation; Welch Foundation; Agricultural Research Service; American Cancer Society; National Institute of Child Health and Human Development; U.S. Department of Agriculture; Howard Hughes Medical Institute","keywords":"Pathogenesis; MECP2; Chromatin; Neuroscience; Biology; Rett syndrome; Genetics; Cell biology; Immunology; Gene; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005717185,0.0001439897,0.00009698411,0.00005452839,0.0000418986,0.00004206352,0.00005708696,0.0001039458,0.000007992069],"category_scores_gemma":[0.00001273317,0.0001304468,0.00002507793,0.00006711195,0.0000513008,0.000006827396,0.00006125387,0.00008344135,0.000002405072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000374104,"about_ca_system_score_gemma":0.0000124499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005182118,"about_ca_topic_score_gemma":0.0001229569,"domain_scores_codex":[0.9992073,0.00002985758,0.0001174291,0.000375734,0.00009992847,0.000169741],"domain_scores_gemma":[0.9998178,0.00001117431,0.00002061658,0.00008208634,0.00001433363,0.00005392489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008626356,0.00001996899,0.006637551,0.00006480512,0.00001301501,0.00001477191,0.00007464304,0.000005758106,0.9860951,0.00007031637,0.00009604608,0.006821739],"study_design_scores_gemma":[0.0005800551,0.000718133,0.942414,0.00002842805,0.00002995262,0.0001608892,0.00003054519,0.0004021666,0.04993466,0.00015395,0.005312769,0.000234393],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974571,0.0008196013,0.00003009023,0.001043493,0.0001729336,0.0001774798,0.00003583044,0.00001681216,0.0002466409],"genre_scores_gemma":[0.9940879,0.004655027,0.0001061486,0.0008121142,0.00002373715,0.00003417788,0.00006356018,0.00001736538,0.000199917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9361604,"threshold_uncertainty_score":0.5319468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033917364044274,"score_gpt":0.2209409304622659,"score_spread":0.2106017568218232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}