{"id":"W4405459405","doi":"10.1038/s41467-024-53548-z","title":"Brain change trajectories in healthy adults correlate with Alzheimer’s related genetic variation and memory decline across life","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Health, Environment, Cognitive Aging","field":"Environmental Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; IXICO; H. Lundbeck A/S; Servier; Universitetet i Oslo; Universitair Medisch Centrum Groningen; Eisai; GGZ Friesland; Genentech; Norges Forskningsråd; Vrije Universiteit Amsterdam; Rivierduinen; ZonMw; Bristol-Myers Squibb; Rijksuniversiteit Groningen; National Institute on Aging; Commonwealth Scientific and Industrial Research Organisation; Northern California Institute for Research and Education; GGZ Drenthe; F. Hoffmann-La Roche; University of Southern California; Pfizer; BioClinica; Biogen; National Institutes of Health; GGZ inGeest; U.S. Department of Defense; Eli Lilly and Company; Universiteit Leiden; Leids Universitair Medisch Centrum; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Alzheimer's Association","keywords":"Variation (astronomy); Genetic variation; Cognitive decline; Neuroscience; Gerontology; Medicine; Biology; Dementia; Genetics; Disease; Gene; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008261465,0.0001664383,0.0001546743,0.00006686833,0.0003176181,0.00005051456,0.000386455,0.0002723444,0.00008723433],"category_scores_gemma":[0.0002397965,0.0001549794,0.00002251651,0.0006280474,0.000311019,0.0003317146,0.0004329721,0.00127112,0.00009056925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002278705,"about_ca_system_score_gemma":0.00005587484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001730959,"about_ca_topic_score_gemma":0.01478728,"domain_scores_codex":[0.9983134,0.0003212859,0.0003186138,0.0004530826,0.0002798282,0.0003137867],"domain_scores_gemma":[0.9983429,0.0005721272,0.00008915456,0.0008275894,0.0000138064,0.0001543658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007803782,0.0009184693,0.4557,0.0002221213,0.0003105645,0.0000696491,0.1806217,0.001152286,0.001020569,0.00138624,0.001366772,0.3564512],"study_design_scores_gemma":[0.0005964912,0.0001328022,0.9804655,0.0001240262,0.00003018744,0.0000197356,0.0004332229,0.01184668,0.00000686798,0.0001622052,0.00599567,0.0001866344],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9455159,0.02218694,0.00015987,0.02970936,0.0001657379,0.001012851,0.00004430966,0.0001271881,0.001077818],"genre_scores_gemma":[0.9909304,0.00304877,0.00278029,0.002922556,0.00002871584,0.0001690751,0.00005935991,0.00003310729,0.0000276995],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5247655,"threshold_uncertainty_score":0.8251647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961781954186396,"score_gpt":0.3190498596206138,"score_spread":0.2894320400787498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}