{"id":"W4405494826","doi":"10.1016/j.omtm.2024.101400","title":"Characterization and effective expansion of CD4−CD8− TCRαβ+ T cells from individuals living with type 1 diabetes","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Bioinformatics Solutions (Canada); Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Diabète Québec","keywords":"T-cell receptor; Type 1 diabetes; CD8; Characterization (materials science); Diabetes mellitus; Type 2 diabetes; Biology; Immunology; Medicine; T cell; Antigen; Endocrinology; Materials science; Immune system; Nanotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001579817,0.0002010603,0.0001906553,0.0002903537,0.0001995932,0.0002614342,0.0001170281,0.0002153283,0.001176076],"category_scores_gemma":[0.0002461936,0.0001119676,0.0001278748,0.0001818698,0.0001071237,0.0001270146,0.0002209082,0.0003927836,0.0003881876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007072905,"about_ca_system_score_gemma":0.00009532143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004164326,"about_ca_topic_score_gemma":0.0003713633,"domain_scores_codex":[0.9998707,0.00001786746,0.0000168604,0.00004143421,0.0000288044,0.00002438678],"domain_scores_gemma":[0.9999288,0.0000159502,0.000008251283,0.00001182917,0.00001424734,0.00002083576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000304506,0.0001325644,0.007625207,0.00004249332,0.000006317326,0.000221569,0.0001925789,0.0001019667,0.9798406,0.00005652599,0.0001000536,0.01137572],"study_design_scores_gemma":[0.0001948767,0.005453868,0.2105377,0.00009196182,0.0001526305,0.008214584,0.000738211,0.002649995,0.7580817,0.0003329419,0.01351308,0.00003849071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967034,0.0004839028,0.0015087,0.00002929609,0.00001218101,0.00008737435,0.0002425922,0.00001327414,0.0009193175],"genre_scores_gemma":[0.9924605,0.0007662162,0.003398188,0.0001219846,0.00003895496,0.0001776842,0.001135321,0.00002039664,0.001880681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176076,"threshold_uncertainty_score":0.003934383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02335294524780427,"score_gpt":0.3355788060842883,"score_spread":0.312225860836484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}