{"id":"W4405498081","doi":"10.7554/elife.100555","title":"Nonlinear transcriptional responses to gradual modulation of transcription factor dosage","year":2024,"lang":"en","type":"preprint","venue":"eLife","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Human Genome Research Institute; Science for Life Laboratory; Knut och Alice Wallenbergs Stiftelse; Canadian Institutes of Health Research; European Commission","keywords":"Biology; Gene; Gene dosage; Chromatin; Gene expression; Genetics; Transcription factor; Computational biology; Regulation of gene expression; Histone; Enhancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003105273,0.0004196029,0.0003870075,0.0001770499,0.0001367781,0.0005325406,0.0003346836,0.0004147172,0.001700884],"category_scores_gemma":[0.0005371312,0.0003083528,0.0003165676,0.0001633659,0.000692706,0.0002747102,0.0006604877,0.001056394,0.0005254656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004849429,"about_ca_system_score_gemma":0.0002072842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006075586,"about_ca_topic_score_gemma":0.001039151,"domain_scores_codex":[0.999648,0.00003195804,0.00002493513,0.0001350178,0.00009198303,0.00006809247],"domain_scores_gemma":[0.999545,0.0001731673,0.00009891215,0.00010242,0.00004161949,0.00003891094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002613073,0.000005199137,0.0003144604,0.00002269911,0.00000466089,0.00001776734,0.00001394814,0.0003159122,0.9979975,0.0001106427,0.00002711766,0.001143976],"study_design_scores_gemma":[0.00000993854,0.00006962482,0.00503237,0.000005187316,0.00001063724,0.00008705145,0.00003350156,0.003622671,0.9892967,0.0002754482,0.001544419,0.00001253032],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438605,0.00065077,0.05064668,0.0002496907,0.0000658998,0.00004727254,0.0008069685,0.000783204,0.002888958],"genre_scores_gemma":[0.9862737,0.0004779914,0.009830629,0.0002136829,0.00001131091,0.00007087391,0.000417766,0.0001983372,0.002505689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001700884,"threshold_uncertainty_score":0.005689979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02189587342405884,"score_gpt":0.3258308681186191,"score_spread":0.3039349946945602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}