{"id":"W4405506971","doi":"10.1016/j.annonc.2024.12.010","title":"Prognostic value of residual disease (RD) biology and gene expression changes during the neoadjuvant treatment in patients with HER2-positive early breast cancer (EBC)","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Lombardi Comprehensive Cancer Center, Georgetown University; Campbell Family Mental Health Research Institute; Samsung; National Institutes of Health; Fondation contre le Cancer; Fondation Rose et Jean Hoguet; Stichting Tegen Kanker; Celltrion; Eisai; Fonds De La Recherche Scientifique - FNRS; Fonds National de la Recherche Luxembourg; Genentech; Veracyte; Seagen; Les Laboratories Pierre Fabre; NSABP Foundation; Queen Mary University of London; Clovis Oncology; Susan G. Komen; Baxalta; Breast Cancer Research Foundation; Ariad Pharmaceuticals; Daiichi Sankyo Europe; National Cancer Institute; Servier; Gilead Sciences; Bayer HealthCare; European Commission; Pfizer; Novartis Pharmaceuticals Corporation; Celgene; Associazione Italiana per la Ricerca sul Cancro; Eli Lilly and Company; AstraZeneca; GlaxoSmithKline","keywords":"Medicine; Breast cancer; Neoadjuvant therapy; Oncology; Minimal residual disease; Internal medicine; Disease; Cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002936566,0.0001350452,0.0002236335,0.0002615344,0.0001201689,0.0003614079,0.0001157821,0.0001943404,0.000645705],"category_scores_gemma":[0.0007202431,0.0000639405,0.000212693,0.0002681602,0.0001628185,0.0001978013,0.0001295021,0.0002301972,0.000088995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001916474,"about_ca_system_score_gemma":0.0001569324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006892446,"about_ca_topic_score_gemma":0.00132009,"domain_scores_codex":[0.9998873,0.00003717075,0.00001165723,0.0000207705,0.00001664963,0.00002637292],"domain_scores_gemma":[0.9996599,0.0001293375,0.00009320724,0.00002859011,0.00002328754,0.0000657951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002984869,0.00008141149,0.9815037,0.0000280931,0.00006954329,0.0001071536,0.00005402933,0.0001655053,0.005205994,0.00002681905,0.00007149018,0.00970133],"study_design_scores_gemma":[0.00001408307,0.0006015655,0.9974024,0.000004988766,0.00008378096,0.0002738785,0.00008690276,0.0002132819,0.0008666808,0.00002795842,0.0004211456,0.000003390829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986235,0.0008081053,0.00003805177,0.00003335088,0.000005456025,0.000002355158,0.00009931366,0.000001419885,0.0003885021],"genre_scores_gemma":[0.999408,0.00016293,0.00004361586,0.00001634834,0.00001107309,0.000003382917,0.0001779143,7.032134e-7,0.0001761398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006892446,"threshold_uncertainty_score":0.002160072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132554136519888,"score_gpt":0.3053748758639135,"score_spread":0.2921194622119247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}