{"id":"W4405510082","doi":"10.1002/anie.202421077","title":"Hydroalkylation of Vinylarenes by Transition‐Metal‐Free In Situ Generation of Benzylic Nucleophiles Using Tetramethyldisiloxane and Potassium <i>tert</i> ‐Butoxide","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Organoboron and organosilicon chemistry","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Government of Ontario","keywords":"Chemistry; Nucleophile; Silylation; Alkylation; Reactive intermediate; Reagent; Lewis acids and bases; SN2 reaction; Alkyl; Intramolecular force; Regioselectivity; Electrophile; Combinatorial chemistry; Radical; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001167043,0.0003453837,0.0001027637,0.0001286624,0.00009462264,0.0001549849,0.0001976409,0.0001567014,0.001305924],"category_scores_gemma":[0.0001111463,0.000128565,0.0001631598,0.00007844986,0.0001492694,0.0001997089,0.0001982127,0.0002257164,0.0002916335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532273,"about_ca_system_score_gemma":0.0001605114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003282896,"about_ca_topic_score_gemma":0.0009838023,"domain_scores_codex":[0.9999371,0.000008728898,0.000004828584,0.00001016398,0.00001339899,0.00002584881],"domain_scores_gemma":[0.9999384,0.00000810114,0.0000251682,0.000007934826,0.000007755564,0.00001264643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000394514,0.00001424763,0.00007475793,0.00004319405,0.000005812685,0.00005651394,0.00002563225,0.000110494,0.9976708,0.0002332716,0.00004989545,0.00167582],"study_design_scores_gemma":[0.000005119563,0.00009178617,0.0002216169,0.000001877299,0.000004882694,0.00003584474,0.00000535445,0.0002063077,0.9984432,0.00001836895,0.0009634936,0.000002175005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909768,0.0004791102,0.004560786,0.00006684813,0.00003023334,0.00002395779,0.0001230328,0.00009765512,0.003641541],"genre_scores_gemma":[0.9960248,0.0003752189,0.001788065,0.00002165771,0.000006921532,0.000006677813,0.0001057498,0.00001902615,0.001651814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001305924,"threshold_uncertainty_score":0.004368782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01592645413640608,"score_gpt":0.2477371269466547,"score_spread":0.2318106728102486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}