{"id":"W4405518235","doi":"10.1093/ecco-jcc/jjae191","title":"Disruption of Epithelial Barrier Integrity via Altered GILZ/c-Rel/RACK1 Signaling in Inflammatory Bowel Disease","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Optech (Canada)","funders":"Servier; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Inflammatory bowel disease; Medicine; Inflammatory Bowel Diseases; Immune system; Cancer research; Signal transduction; Kinase; Immunology; Disease; Cell biology; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501145,0.0003879202,0.0003032566,0.0003244399,0.0002188791,0.0003515071,0.0001684125,0.0003771125,0.001072918],"category_scores_gemma":[0.00009631406,0.000135334,0.0003585735,0.0001555498,0.0003356237,0.0001835644,0.0002113335,0.0006522136,0.00027024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503781,"about_ca_system_score_gemma":0.0001817214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002755141,"about_ca_topic_score_gemma":0.0004285983,"domain_scores_codex":[0.9998689,0.00001999062,0.0000104101,0.00002998407,0.00002657357,0.00004413077],"domain_scores_gemma":[0.9998912,0.000006020673,0.00005033328,0.000008102998,0.00001158978,0.00003285187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007976166,0.00005167528,0.002239775,0.0002628929,0.00002940247,0.0003782541,0.00003731001,0.0001322098,0.9921395,0.0001709196,0.0001284171,0.003631951],"study_design_scores_gemma":[0.000150345,0.001182709,0.165958,0.00008392231,0.0002874597,0.004202846,0.0004179911,0.003101323,0.8139743,0.0004689197,0.01013643,0.00003584878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898656,0.007008264,0.001622223,0.0002776623,0.00003717607,0.00001956064,0.0003128875,0.0001371023,0.0007195243],"genre_scores_gemma":[0.996462,0.001765158,0.0007734663,0.00006646875,0.00001193672,0.00001621518,0.0002370612,0.00001195332,0.0006558088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001072918,"threshold_uncertainty_score":0.003589272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00873924267897323,"score_gpt":0.2562790459590268,"score_spread":0.2475398032800536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}