{"id":"W4405525093","doi":"10.1038/s41419-024-07304-2","title":"DARPins as a novel tool to detect and degrade p73","year":2024,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung; Ontario Genomics Institute; Merck KGaA; Ontario Genomics; Genome Canada; Genentech; Bayer; Universität Zürich; Pfizer; Deutsche Forschungsgemeinschaft; Bristol-Myers Squibb","keywords":"Ankyrin repeat; Ubiquitin ligase; DNA ligase; Biology; Small molecule; Transcription factor; Protein–protein interaction; Plasma protein binding; Cell biology; DNA-binding protein; Signal transducing adaptor protein; Computational biology; Proximity ligation assay; Ubiquitin; Biochemistry; DNA; Signal transduction; Gene; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001543026,0.0005230253,0.0003418009,0.0004213532,0.0001808549,0.0003646805,0.0002688243,0.000413498,0.0007390326],"category_scores_gemma":[0.0001307834,0.0001682746,0.0002867704,0.0001825723,0.0002200964,0.0002880594,0.0002181455,0.0005911993,0.0004216724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002524444,"about_ca_system_score_gemma":0.000151061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551443,"about_ca_topic_score_gemma":0.0002686032,"domain_scores_codex":[0.9998202,0.00002564735,0.00001080388,0.00004593015,0.00007262151,0.00002484724],"domain_scores_gemma":[0.9999084,0.00001875836,0.00002785769,0.000009325712,0.00001370114,0.00002190902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001224032,0.000004795089,0.00002894977,0.00002157746,0.000002798496,0.0000523569,0.000005983176,0.00004411829,0.9982344,0.00009492616,0.00003637811,0.00146143],"study_design_scores_gemma":[0.000005579845,0.00007271978,0.0005750636,0.000003330677,0.000005209725,0.0004137668,0.000005566717,0.0008165189,0.9935041,0.00005590325,0.004537343,0.000004941829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8430028,0.008921949,0.1406701,0.0004925749,0.0001566084,0.0001880382,0.0007592977,0.001477464,0.004331224],"genre_scores_gemma":[0.8789844,0.004623355,0.1048393,0.0004064039,0.00007066563,0.0001892436,0.001586495,0.0001181065,0.009182035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007390326,"threshold_uncertainty_score":0.002472341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008301515021582388,"score_gpt":0.2387430720528698,"score_spread":0.2304415570312874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}