{"id":"W4405529717","doi":"10.1101/cshperspect.a041708","title":"Maintaining Telomeres without Telomerase in<i>Drosophila</i>: Novel Mechanisms and Rapid Evolution to Save a Genus","year":2024,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Biology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"National Institute of General Medical Sciences","keywords":"Biology; Telomere; Telomerase; Drosophila (subgenus); Genus; Evolutionary biology; Genetics; Zoology; Computational biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005619636,0.000688126,0.001229911,0.0007027889,0.00008559365,0.0000654096,0.0004470081,0.0007571999,0.000009616138],"category_scores_gemma":[0.00026067,0.0006679807,0.0002280438,0.0003846944,0.0002402196,0.000006638708,0.000652738,0.0006515462,0.00002360622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003955941,"about_ca_system_score_gemma":0.0003011435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001774056,"about_ca_topic_score_gemma":0.0002371889,"domain_scores_codex":[0.9967607,0.0002055382,0.0006318407,0.001581444,0.0001196727,0.0007008527],"domain_scores_gemma":[0.9988973,0.00004548009,0.0001795276,0.0006293948,0.00007247695,0.0001758201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003132326,0.001090002,0.001956161,0.01002349,0.001767448,0.0002754225,0.005059783,0.000326463,0.4876105,0.4215446,0.0001198202,0.06991306],"study_design_scores_gemma":[0.002821324,0.002602315,0.003274992,0.01017028,0.001241745,0.0001638196,0.001784341,0.0003509518,0.003084392,0.001970313,0.9672825,0.005252969],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01036304,0.982856,0.005033602,0.00009953721,0.0005170354,0.0008804032,0.00008854425,0.00004487618,0.0001168955],"genre_scores_gemma":[0.2190479,0.7757087,0.004306185,0.0000863222,0.0004273723,0.0002298383,0.00001552664,0.0001213495,0.00005684311],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9671627,"threshold_uncertainty_score":0.9995772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377752143722142,"score_gpt":0.305563415268474,"score_spread":0.2817858938312525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}