{"id":"W4405535345","doi":"10.1016/s1474-4422(24)00447-2","title":"Safety and efficacy of intrathecal antibodies to Nogo-A in patients with acute cervical spinal cord injury: a randomised, double-blind, multicentre, placebo-controlled, phase 2b trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Spinal Cord Injury Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries","funders":"Eidgenössische Technische Hochschule Zürich; Bundesministerium für Bildung und Forschung; Universität Zürich; Deutsche Forschungsgemeinschaft; H2020 European Research Council; Wings for Life","keywords":"Medicine; Placebo; Double blind; Spinal cord injury; Randomized controlled trial; Anesthesia; Intrathecal; Spinal cord; Surgery; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002688126,0.002462765,0.004241917,0.0006494326,0.000672782,0.001587769,0.00122701,0.003821344,0.006207381],"category_scores_gemma":[0.00324718,0.0009915857,0.002035995,0.000565287,0.001576544,0.001432189,0.0005190433,0.002628725,0.001372958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001038625,"about_ca_system_score_gemma":0.001770915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001005371,"about_ca_topic_score_gemma":0.001805509,"domain_scores_codex":[0.9986194,0.0007400722,0.0001092593,0.0002626481,0.00008857626,0.0001800271],"domain_scores_gemma":[0.9986992,0.0003458466,0.0003363112,0.0001069448,0.0001363623,0.0003753909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9876419,0.00346303,0.0003541355,0.0006998618,0.0003652862,0.00002749029,0.00004014913,0.0001098528,0.001330668,0.00003858219,0.0003394839,0.005589467],"study_design_scores_gemma":[0.9726833,0.0261618,0.0006111625,0.00002291832,0.0001233525,0.00001104708,0.000007714994,0.00008063318,0.00008192523,0.0000342979,0.0001753279,0.000006573357],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977096,0.007909071,0.0005999947,0.001155887,0.0007818671,0.009350445,0.001267424,0.0001327661,0.001706517],"genre_scores_gemma":[0.9719689,0.004415395,0.00169918,0.001767143,0.0008432588,0.01523358,0.001274746,0.00002716884,0.002770515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006207381,"threshold_uncertainty_score":0.02076572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04676489466065083,"score_gpt":0.4001762883629379,"score_spread":0.3534113937022871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}