{"id":"W4405549938","doi":"10.1186/s12864-024-11031-5","title":"Computational deconvolution of cell type-specific gene expression in COPD and IPF lungs reveals disease severity associations","year":2024,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Alpha-1 Foundation","keywords":"DLCO; COPD; Idiopathic pulmonary fibrosis; Lung; Diffusing capacity; Pathology; Population; Cell type; Medicine; Biology; Cell; Immunology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699712,0.00007065323,0.00008436281,0.0000583946,0.00003326803,0.00002011186,0.00006453784,0.00006428867,0.00001633959],"category_scores_gemma":[0.00006534507,0.00007820604,0.00003215915,0.0000886268,0.00003577378,0.000004998904,0.00009199846,0.0000629822,0.000007480634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008787507,"about_ca_system_score_gemma":0.0001647605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009077692,"about_ca_topic_score_gemma":0.00002866814,"domain_scores_codex":[0.9993443,0.00006873158,0.0001506489,0.0002334848,0.00008735906,0.0001154676],"domain_scores_gemma":[0.9996551,0.00005338077,0.00003492142,0.0001160192,0.00007579831,0.00006476517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00006725288,0.00003984405,0.07199222,0.00007745504,0.000008290199,0.00000207253,0.0001007658,0.0005873284,0.9260508,0.00009196925,0.0007795981,0.0002023777],"study_design_scores_gemma":[0.0005615304,0.0000688713,0.7570675,0.00003401264,0.00001375462,0.000002575777,0.00006115824,0.004046983,0.2311946,0.001820237,0.004910001,0.000218734],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910338,0.004380621,0.004049371,0.00002977762,0.00007376237,0.0001790959,0.0001743715,0.000005987996,0.00007321429],"genre_scores_gemma":[0.9961918,0.0002160374,0.003002438,0.00001028443,0.00006068663,0.000007756051,0.0003040037,0.00001241691,0.0001945838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6948562,"threshold_uncertainty_score":0.3189149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466440913189915,"score_gpt":0.2858544073168643,"score_spread":0.2611899981849651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}