{"id":"W4405562962","doi":"10.17615/dyhg-n602","title":"Targeting Nav1.7 and Nav1.8 with a PIKfyve inhibitor to Reverse inflammatory and neuropathic pain","year":2024,"lang":"en","type":"article","venue":"UNC Libraries","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Drug Abuse; Ontario Genomics; National Institutes of Health; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; McGill University; Genentech; Bayer; Pfizer","keywords":"NAV1; Neuropathic pain; Medicine; Neuroscience; Pharmacology; Chemistry; Sodium channel; Biology; Sodium","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002964559,0.0001407882,0.00009958421,0.00004566086,0.00008681718,0.0001622097,0.00005573904,0.00007703648,0.00001062893],"category_scores_gemma":[0.0001638065,0.0001125212,0.00001775572,0.00009078256,0.00009086716,0.00002146015,0.0001430222,0.0001025212,0.000003638243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002425097,"about_ca_system_score_gemma":0.0000752226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007401648,"about_ca_topic_score_gemma":0.000001528071,"domain_scores_codex":[0.9992238,0.0001003103,0.0001227849,0.0003124915,0.00007811432,0.0001625054],"domain_scores_gemma":[0.9996861,0.0000624307,0.00002096205,0.0001135823,0.00002048525,0.00009643083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006268257,0.00004223338,0.02135739,0.001059546,0.0002154277,0.0006761752,0.003990235,0.0002075478,0.6598707,0.02120224,0.2836928,0.007058871],"study_design_scores_gemma":[0.0008052324,0.001462727,0.000775494,0.0006994565,0.00008668697,0.0001977648,0.001597413,0.001375566,0.1465195,0.002585026,0.8428139,0.001081213],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732421,0.02007616,0.004770491,0.001226792,0.0001282955,0.0001792761,0.00001067207,0.0000744611,0.000291748],"genre_scores_gemma":[0.9918482,0.00007179023,0.004413819,0.001830492,0.0006854306,0.00001742935,0.00003504368,0.00004328883,0.001054451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5591211,"threshold_uncertainty_score":0.4588483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004598300689702423,"score_gpt":0.188382458334288,"score_spread":0.1837841576445856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}