{"id":"W4405566880","doi":"10.3390/molecules29245997","title":"Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids","year":2024,"lang":"en","type":"review","venue":"Molecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; Muscular Dystrophy Canada; University of Alberta; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute; Alberta Innovates; Heart and Stroke Foundation of Canada; U.S. Department of Defense","keywords":"Endosome; Endocytosis; RNA interference; Nucleic acid; Small interfering RNA; Cell biology; Nuclear localization sequence; Biology; Nuclear transport; RNA; Oligonucleotide; Computational biology; Cell nucleus; Cell; Gene; Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004594811,0.0007214717,0.001020203,0.001005048,0.000290095,0.001099607,0.0006757494,0.001145941,0.001994709],"category_scores_gemma":[0.0003368237,0.0002803686,0.0003789544,0.0009253888,0.0006289036,0.001511335,0.0007266346,0.001879533,0.001351647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009207043,"about_ca_system_score_gemma":0.001198023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008044553,"about_ca_topic_score_gemma":0.001121902,"domain_scores_codex":[0.9997666,0.00004191642,0.00002376004,0.00003522675,0.0001040392,0.000028501],"domain_scores_gemma":[0.9998592,0.00007150319,0.00001767585,0.000004511178,0.00003629111,0.00001088491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000648183,0.00005784312,0.0001158929,0.01908357,0.00007151083,0.0004081941,0.0001850092,0.0007356419,0.01718105,0.03412876,0.02624513,0.9017225],"study_design_scores_gemma":[0.000008310588,0.00006101104,0.0002716583,0.001280331,0.00003622294,0.0009961569,0.00006863765,0.0001095212,0.002395546,0.003490749,0.9912671,0.00001466691],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002248695,0.9973369,0.0004657372,0.0003762334,0.0001585645,0.000004210115,0.000008978684,0.00001038231,0.001414148],"genre_scores_gemma":[0.001254404,0.9969844,0.0003537285,0.0002373995,0.00008562822,0.00001050321,0.00001961947,0.000002380883,0.001051945],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001994709,"threshold_uncertainty_score":0.006680191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395058590558634,"score_gpt":0.3207766069588148,"score_spread":0.2968260210532285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}