{"id":"W4405566880","doi":"10.3390/molecules29245997","title":"Endosomal Escape and Nuclear Localization: Critical Barriers for Therapeutic Nucleic Acids","year":2024,"lang":"en","type":"review","venue":"Molecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Muscular Dystrophy Canada; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; Muscular Dystrophy Canada; University of Alberta; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute; Alberta Innovates; Heart and Stroke Foundation of Canada; U.S. Department of Defense","keywords":"Endosome; Endocytosis; RNA interference; Nucleic acid; Small interfering RNA; Cell biology; Nuclear localization sequence; Biology; Nuclear transport; RNA; Oligonucleotide; Computational biology; Cell nucleus; Cell; Gene; Cytoplasm; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0000744213,0.0003586666,0.0005028183,0.00007414076,0.0001076073,0.0001281594,0.0002325733,0.0004143406,0.00004759552],"category_scores_gemma":[0.0000770571,0.000295286,0.000355543,0.00007749923,0.0001691837,0.000003587928,0.0001507833,0.0001402341,0.0000542552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001373431,"about_ca_system_score_gemma":0.0001286883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001409348,"about_ca_topic_score_gemma":0.000001782748,"domain_scores_codex":[0.9986874,0.00006909853,0.0002899525,0.0005830919,0.00009453941,0.000275908],"domain_scores_gemma":[0.9994297,0.00002452826,0.00004812417,0.0003009771,0.0000631779,0.0001335099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008848097,0.00006217563,0.000004388231,0.02095744,0.001260616,0.00006230812,0.0001492047,0.000002666283,0.002879985,0.01127129,0.02506933,0.9381921],"study_design_scores_gemma":[0.00009493047,0.0002967568,2.100445e-7,0.001075864,0.0007508717,0.00006686591,0.00004544035,0.0001149612,0.000149447,0.0002247916,0.996846,0.0003339126],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006422489,0.9964033,0.002254338,0.00007432159,0.0003053244,0.0003442615,0.0001331236,0.00002735674,0.000393766],"genre_scores_gemma":[0.001552235,0.9966547,0.0002589319,0.0004463486,0.0003343734,0.00009557181,0.0002361696,0.0001103256,0.0003113006],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9717766,"threshold_uncertainty_score":0.9999499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395058590558634,"score_gpt":0.3207766069588148,"score_spread":0.2968260210532285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}