{"id":"W4405566984","doi":"10.1016/j.cell.2024.11.020","title":"A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; McMaster University; Population Health Research Institute; University of Toronto","funders":"NHLBI Division of Intramural Research; Canadian Institutes of Health Research; University of Toronto; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Institutes of Health; Science Foundation Ireland; J.P. Bickell Foundation; University of British Columbia; Canadian Allergy, Asthma and Immunology Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Biology; Immunity; Disease; Immunology; Respiratory system; Mucosal immunity; Pulmonary disease; Microbiology; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000873612,0.0001482886,0.0001529214,0.00007735509,0.0002137758,0.00004306104,0.0001691161,0.00009049322,0.0007406604],"category_scores_gemma":[0.00002463581,0.000124863,0.0001204828,0.0000688188,0.0001141619,0.0001243869,0.00008551964,0.000329485,0.001519933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002595637,"about_ca_system_score_gemma":0.00004762585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000568195,"about_ca_topic_score_gemma":0.000006371252,"domain_scores_codex":[0.9992274,0.0001079125,0.0001931596,0.0002146857,0.00002078736,0.0002360793],"domain_scores_gemma":[0.9994926,0.0001450143,0.0000324079,0.0002671916,0.00002401896,0.00003870753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008268986,0.0002775612,0.04899557,0.0001041377,0.00009511799,0.00008413356,0.0002146568,6.662061e-7,0.883547,0.00008413226,0.06361693,0.002897367],"study_design_scores_gemma":[0.000318191,0.00006915291,0.04065768,0.00009483793,0.00006781668,0.0000193634,0.0001454814,0.00004821928,0.02842127,0.0001272555,0.9297556,0.0002751364],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748483,0.01529002,0.00004584187,0.0007779922,0.001191099,0.000445047,0.0002208463,0.0002435127,0.006937368],"genre_scores_gemma":[0.9832074,0.00002392693,0.000009228271,0.0008489407,0.00002862776,0.0001225684,0.0001327454,0.00002023339,0.01560632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8661386,"threshold_uncertainty_score":0.9992575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03277817277746032,"score_gpt":0.3159742422674858,"score_spread":0.2831960694900255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}