{"id":"W4405566984","doi":"10.1016/j.cell.2024.11.020","title":"A gut commensal protozoan determines respiratory disease outcomes by shaping pulmonary immunity","year":2024,"lang":"en","type":"article","venue":"Cell","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":65,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; McMaster University; Population Health Research Institute; University of Toronto","funders":"NHLBI Division of Intramural Research; Canadian Institutes of Health Research; University of Toronto; Canadian HIV Trials Network, Canadian Institutes of Health Research; National Institutes of Health; Science Foundation Ireland; J.P. Bickell Foundation; University of British Columbia; Canadian Allergy, Asthma and Immunology Foundation; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Biology; Immunity; Disease; Immunology; Respiratory system; Mucosal immunity; Pulmonary disease; Microbiology; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001946455,0.000181951,0.0002323195,0.0002383284,0.0002668379,0.0006992955,0.0001223211,0.0004528543,0.002148364],"category_scores_gemma":[0.000375461,0.000125538,0.0001315394,0.0001133563,0.000314524,0.0002426905,0.0003704399,0.0006021509,0.0004538333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002077654,"about_ca_system_score_gemma":0.0002031482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002406842,"about_ca_topic_score_gemma":0.0008081159,"domain_scores_codex":[0.9997415,0.0000678993,0.000009971328,0.00004342576,0.00003883487,0.00009833354],"domain_scores_gemma":[0.9997917,0.00003330387,0.00004505764,0.00001521809,0.00002706122,0.00008775155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007151843,0.00009879746,0.0717005,0.00008451562,0.00002887315,0.0005310727,0.000173504,0.0001412634,0.9130618,0.0007665577,0.0005352637,0.01216279],"study_design_scores_gemma":[0.00005252761,0.001114258,0.8539796,0.00009394222,0.0001300194,0.001982622,0.002115802,0.002309119,0.1294219,0.001345682,0.007421299,0.00003334766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960526,0.0009423993,0.0005106258,0.0002212314,0.00003873318,0.00001139924,0.0001045852,0.00001934017,0.002099056],"genre_scores_gemma":[0.9981786,0.000365329,0.0003366861,0.00008642766,0.00002816598,0.000006178824,0.00005848518,0.000007082557,0.0009330392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002148364,"threshold_uncertainty_score":0.007187009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03277817277746032,"score_gpt":0.3159742422674858,"score_spread":0.2831960694900255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}