{"id":"W4405576837","doi":"10.1093/rpsppr/rqae031","title":"Successful treatment of invasive <i>Aspergillus</i> rhinosinusitis and orbital aspergillosis with oral isavuconazole in a patient with contraindications to conventional first- and second-line therapy","year":2024,"lang":"en","type":"article","venue":"RPS Pharmacy and Pharmacology Reports","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; St. Joseph’s Healthcare Hamilton; St Joseph's Health Care","funders":"","keywords":"Voriconazole; Medicine; Aspergillosis; Sinusitis; Surgery; Mucormycosis; Caspofungin; Amphotericin B; Fungal sinusitis; Paranasal sinuses; Mycosis; Contraindication; Radiology; Dermatology; Antifungal; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002278681,0.001105807,0.001007935,0.0009210466,0.00154139,0.001048411,0.0006922678,0.002597966,0.001093228],"category_scores_gemma":[0.0008600972,0.0004791353,0.001502783,0.0004701432,0.0009087559,0.001251205,0.0009677648,0.002548029,0.0006761556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000840768,"about_ca_system_score_gemma":0.001140209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001625573,"about_ca_topic_score_gemma":0.002938857,"domain_scores_codex":[0.9996547,0.00003261487,0.00004964631,0.00005869328,0.00006096138,0.0001433156],"domain_scores_gemma":[0.9996371,0.00006204921,0.00007012534,0.00003554994,0.00002198547,0.0001732137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0000560211,0.000072958,0.005036282,0.00004536766,0.00001128859,0.9861019,0.0001542859,0.0001064058,0.002327878,0.0001830873,0.0005334884,0.005371045],"study_design_scores_gemma":[0.00003259051,0.0001723621,0.005017778,0.00005693967,0.00002467907,0.9900093,0.0002027293,0.0005727114,0.001488197,0.0002042048,0.002198024,0.00002056919],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9444378,0.01204248,0.008102956,0.008114887,0.001247623,0.0002846566,0.0002328415,0.0004550509,0.02508163],"genre_scores_gemma":[0.9900233,0.002379887,0.002824393,0.001813993,0.000805789,0.00003732143,0.0001416286,0.00004054694,0.001933026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002597966,"threshold_uncertainty_score":0.006100237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01847730603760706,"score_gpt":0.3078034873121093,"score_spread":0.2893261812745022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}