{"id":"W4405580693","doi":"10.1186/s13048-024-01572-4","title":"Metformin protects prepubertal mice ovarian reserve against cyclophosphamide via regulation of the PI3K/Akt/mTOR signaling pathway and Yap-1","year":2024,"lang":"en","type":"article","venue":"Journal of Ovarian Research","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe","funders":"Royan Institute","keywords":"Cyclophosphamide; PI3K/AKT/mTOR pathway; Metformin; Medicine; Downregulation and upregulation; Endocrinology; Folliculogenesis; Internal medicine; Protein kinase B; Ovarian reserve; Follicular phase; Ovary; Signal transduction; Andrology; Biology; Infertility; Chemotherapy; Insulin; Pregnancy; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00831869,0.000140486,0.0003709428,0.0003067942,0.0001983178,0.00004927158,0.0002964118,0.0002106299,0.00007511541],"category_scores_gemma":[0.003472693,0.00008409731,0.000178949,0.0007363032,0.0003903011,0.0002668043,0.0002066534,0.001282456,0.000003672533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001510201,"about_ca_system_score_gemma":0.0006912026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009079099,"about_ca_topic_score_gemma":0.000009513704,"domain_scores_codex":[0.9970843,0.0007206984,0.000687869,0.0003463236,0.0008262036,0.000334653],"domain_scores_gemma":[0.9978268,0.0004614919,0.0002185645,0.0005139287,0.0008130386,0.0001662152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006232378,0.0001906741,0.006421013,0.0005917638,0.0003755435,0.0002069451,0.001259113,0.00001810274,0.9648268,0.0005638103,0.000501163,0.01881271],"study_design_scores_gemma":[0.001255118,0.001179133,0.3770861,0.001250483,0.00007869177,0.0008773129,0.0003331114,0.0008841858,0.6031232,0.01025033,0.003544564,0.0001377187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903626,0.003071315,0.0004823213,0.003627206,0.0003502845,0.0008644251,0.000006926703,0.0000120332,0.001222917],"genre_scores_gemma":[0.9969347,0.00004720662,0.00150546,0.00002960988,0.0005354971,0.00001252629,0.000002737786,0.0000204429,0.0009118678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3706651,"threshold_uncertainty_score":0.5571702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05076294180931092,"score_gpt":0.3393154901983636,"score_spread":0.2885525483890527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}