{"id":"W4405582829","doi":"10.1093/humrep/deae269","title":"Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study","year":2024,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; B.C. Women's Hospital & Health Centre; Women's Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Alberta Precision Laboratories; Society for the Study of Reproduction; Michael Smith Health Research BC; Pfizer","keywords":"PTEN; ARID1A; Endometriosis; Medicine; Tensin; Oncology; Internal medicine; Biology; Genetics; Mutation; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000203783,0.00009993587,0.00008891902,0.00006271672,0.0001146515,0.00008381315,0.00003563523,0.00003094245,0.00001178447],"category_scores_gemma":[0.00008983551,0.00009136078,0.00003023616,0.00008285521,0.00005439275,0.000005126056,0.00006132524,0.00005663625,0.000002919127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001152484,"about_ca_system_score_gemma":0.00001897214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003951524,"about_ca_topic_score_gemma":0.00001198237,"domain_scores_codex":[0.9990615,0.00002893902,0.00012912,0.0005846331,0.00009726061,0.00009851732],"domain_scores_gemma":[0.9995646,0.000006420886,0.00002433939,0.0003150445,0.00003014951,0.00005945557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003629891,0.0006791932,0.1217951,0.001899771,0.0008897384,0.0001630222,0.003120698,0.0004995182,0.6927085,0.0003938617,0.002430558,0.1750571],"study_design_scores_gemma":[0.00711727,0.00468003,0.823199,0.00107834,0.002429328,0.001453366,0.004774719,0.009820819,0.08307192,0.009933472,0.04915712,0.003284628],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882225,0.0109203,0.0001872827,0.0002007512,0.0001665912,0.000199098,0.000003280873,0.00003725157,0.00006297631],"genre_scores_gemma":[0.9979001,0.0003330386,0.00005641045,0.000007647836,0.0007674638,0.00002983608,0.00001917417,0.00001541122,0.0008708751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7014039,"threshold_uncertainty_score":0.3725584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531124437360985,"score_gpt":0.3058752735287698,"score_spread":0.2805640291551599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}