{"id":"W4405582829","doi":"10.1093/humrep/deae269","title":"Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study","year":2024,"lang":"en","type":"article","venue":"Human Reproduction","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; B.C. Women's Hospital & Health Centre; Women's Health Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Alberta Precision Laboratories; Society for the Study of Reproduction; Michael Smith Health Research BC; Pfizer","keywords":"PTEN; ARID1A; Endometriosis; Medicine; Tensin; Oncology; Internal medicine; Biology; Genetics; Mutation; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003005476,0.0002211729,0.0002991,0.0005342364,0.0007465251,0.0006297877,0.0004321845,0.0004393805,0.001141837],"category_scores_gemma":[0.003486342,0.0003718859,0.0006104102,0.0008800841,0.0002623656,0.0008818301,0.0006392347,0.0008014109,0.00029133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003195275,"about_ca_system_score_gemma":0.000542938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004628226,"about_ca_topic_score_gemma":0.006556949,"domain_scores_codex":[0.9992287,0.0002923232,0.00007812912,0.0001897639,0.00009521965,0.00011586],"domain_scores_gemma":[0.9979318,0.0002840959,0.0007999308,0.000304592,0.0003176445,0.0003618968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002201903,0.00007071051,0.9982345,0.0000118612,0.0001237711,0.00003141137,0.0001146436,0.00001794148,0.0001459743,0.00002403639,0.0001187844,0.0008862297],"study_design_scores_gemma":[0.00004971301,0.0006679257,0.9974481,0.00002853428,0.0001975791,0.0002468693,0.0004305356,0.0002385335,0.0001104369,0.00007996472,0.0004922001,0.000009666023],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981955,0.0004256262,0.0003193874,0.0001052107,0.00001052126,0.00003301513,0.0006505616,0.00000399953,0.0002563571],"genre_scores_gemma":[0.9983772,0.000179329,0.0003732365,0.0000754043,0.00001791374,0.00005351944,0.0006873721,0.000002197251,0.0002338601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004628226,"threshold_uncertainty_score":0.01589465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531124437360985,"score_gpt":0.3058752735287698,"score_spread":0.2805640291551599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}