{"id":"W4405586977","doi":"10.3390/cells13242103","title":"Intervertebral Disc Degeneration and Regeneration: New Molecular Mechanisms and Therapeutics: Obstacles and Potential Breakthrough Technologies","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Degeneration (medical); Compartmentalization (fire protection); Degenerative disc disease; Medicine; Intervertebral disc; Modalities; Regeneration (biology); Disease; Low back pain; Clinical Practice; Neuroscience; Pathology; Physical therapy; Psychology; Surgery; Biology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00007527458,0.0003988359,0.0009211282,0.0001773289,0.00005602012,0.0001364697,0.0000825563,0.0004618219,0.00002938071],"category_scores_gemma":[0.00001225089,0.0002775473,0.0001780941,0.000116435,0.0001507058,0.0001021083,0.0002200027,0.0003236919,0.00002316759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003108645,"about_ca_system_score_gemma":0.00008365688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000131382,"about_ca_topic_score_gemma":0.000007338865,"domain_scores_codex":[0.9986463,0.00005844994,0.0004022333,0.000575798,0.0001149841,0.0002021963],"domain_scores_gemma":[0.9995117,0.000005384725,0.0001031487,0.0002756035,0.00002920086,0.00007494793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000003203824,0.00002780818,3.202284e-7,0.00508896,0.0002661592,0.0001851821,0.00008583246,1.298103e-7,0.008690873,0.004542261,0.0020627,0.9790466],"study_design_scores_gemma":[0.003067089,0.00411574,0.00003391259,0.03310655,0.02528802,0.008511439,0.001022873,0.001475724,0.07360406,0.02615723,0.8208102,0.002807139],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003680339,0.9897186,0.007878975,0.0008147096,0.0003971298,0.0005494934,0.00002569853,0.0001410647,0.000106363],"genre_scores_gemma":[0.0009364437,0.9926916,0.00428855,0.0002406932,0.0001801041,0.00003476958,0.0001301079,0.00005762848,0.001440107],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9762394,"threshold_uncertainty_score":0.9999677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03582048153581364,"score_gpt":0.3210290298133049,"score_spread":0.2852085482774913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}