{"id":"W4405589202","doi":"10.1182/blood.2024026299","title":"Long-term efficacy and safety of danicopan as add-on therapy to ravulizumab or eculizumab in PNH with significant EVH","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Samsung; Novo Nordisk; Argenx; Incyte; Regeneron Pharmaceuticals; Alexion Pharmaceuticals; Swedish Orphan Biovitrum; Apellis Pharmaceuticals; BioCryst; Janssen Pharmaceuticals; Gilead Sciences; Sanofi; Celgene; Universität Ulm; Bristol-Myers Squibb; AstraZeneca; Amgen; Pfizer; Chugai Pharmaceutical; Agios Pharmaceuticals","keywords":"Eculizumab; Medicine; Term (time); Intensive care medicine; Pediatrics; Immunology; Antibody; Complement system; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001372681,0.0002095154,0.0003371692,0.00017433,0.00005340146,0.0000234887,0.0002034382,0.00008248157,0.001153751],"category_scores_gemma":[0.00004171269,0.0001421861,0.00004533065,0.0002284363,0.0000897573,0.000040822,0.00007012877,0.0001347033,0.0001837883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002978522,"about_ca_system_score_gemma":0.0001479071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006812985,"about_ca_topic_score_gemma":0.0001245151,"domain_scores_codex":[0.9987196,0.0001701298,0.0003425618,0.0004266105,0.00006181275,0.000279297],"domain_scores_gemma":[0.9992191,0.0002966716,0.00005709316,0.0003585952,0.00002794997,0.00004063225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.05159263,0.008981476,0.1219481,0.001277213,0.0038405,0.001613475,0.007408874,0.00006024344,0.7131317,0.006204146,0.004748914,0.07919265],"study_design_scores_gemma":[0.04197685,0.01196047,0.6927798,0.003441311,0.0003669769,0.0005487828,0.0006098414,0.000002651358,0.2353218,0.00006365569,0.01199655,0.0009313727],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938794,0.004041933,0.00001326377,0.000154256,0.0001486501,0.0009738776,0.000090399,0.00007578672,0.0006224156],"genre_scores_gemma":[0.999117,0.0001353781,0.00001873131,0.00007559406,0.00002424181,0.00006706119,0.0000544477,0.00002684971,0.0004806711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5708316,"threshold_uncertainty_score":0.9997593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01853142794094673,"score_gpt":0.2812584213902983,"score_spread":0.2627269934493516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}