{"id":"W4405595441","doi":"10.1186/s13395-024-00367-x","title":"Wnt7a is required for regeneration of dystrophic skeletal muscle","year":2024,"lang":"en","type":"article","venue":"Skeletal Muscle","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Defeat Duchenne Canada; Ontario Institute for Regenerative Medicine; Stem Cell Network","keywords":"Duchenne muscular dystrophy; Regeneration (biology); Cardiotoxin; Muscular dystrophy; mdx mouse; Skeletal muscle; MYF5; Biology; Myogenesis; Cell biology; Anatomy; Dystrophin; Genetics; Myogenin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127184,0.0003616106,0.0003661811,0.0002804034,0.0002299323,0.0003835414,0.0001625675,0.000440091,0.001535509],"category_scores_gemma":[0.0001419794,0.0002462056,0.0003048004,0.0001252735,0.0003762618,0.0002375295,0.0002829638,0.0004978324,0.0007474583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995085,"about_ca_system_score_gemma":0.0004172627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100177,"about_ca_topic_score_gemma":0.002078639,"domain_scores_codex":[0.9997777,0.00002543518,0.00003089632,0.00004438619,0.00008601262,0.0000355911],"domain_scores_gemma":[0.9998326,0.00001667322,0.00007410401,0.00001037444,0.0000148805,0.00005123156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003376588,0.00000479347,0.0002033095,0.00002944037,0.000003366795,0.00006088509,0.000004518889,0.00002210715,0.9991124,0.0000602214,0.00001760654,0.0004475396],"study_design_scores_gemma":[0.00001853133,0.0001423,0.01728962,0.00002561318,0.00002524429,0.0007134473,0.00005226404,0.0008748979,0.9767787,0.00008591692,0.003987564,0.000005827449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842434,0.005973929,0.005461537,0.0002747378,0.00005496926,0.00003669559,0.001186222,0.0002071167,0.00256148],"genre_scores_gemma":[0.9865753,0.002486611,0.003435035,0.00008232333,0.0000105755,0.00006192381,0.001272258,0.00006135606,0.00601469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001535509,"threshold_uncertainty_score":0.005136788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211795484492028,"score_gpt":0.2639937807627879,"score_spread":0.2518758259178676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}