{"id":"W4405596769","doi":"10.1016/j.antiviral.2024.106061","title":"HBV serum RNA kinetics during nucleic acid polymers based therapy predict functional cure","year":2024,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"BioPhage Pharma (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Nucleic acid; Kinetics; RNA; Chemistry; Virology; Medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005949059,0.0001882495,0.0002483528,0.0004523594,0.0002756116,0.00009710778,0.0001336528,0.0001209959,0.0008483805],"category_scores_gemma":[0.0002228532,0.0001527876,0.0001403815,0.0008466628,0.0003380771,0.0001410261,0.0001266733,0.0008354409,0.0006759039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688178,"about_ca_system_score_gemma":0.0003193521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001890586,"about_ca_topic_score_gemma":0.00007066767,"domain_scores_codex":[0.9970946,0.0001707002,0.0002314898,0.0004537525,0.001324502,0.0007249662],"domain_scores_gemma":[0.9991055,0.0002177756,0.00001672155,0.0003273149,0.0002203768,0.000112341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008496649,0.0003620754,0.07994938,0.0005883781,0.0004268212,0.001084759,0.001129353,0.000001456339,0.830406,0.0002826478,0.03731658,0.04760294],"study_design_scores_gemma":[0.002055876,0.001452456,0.4565666,0.000756783,0.00004160054,0.00002631434,0.0004021431,0.002565928,0.5083689,0.0001000736,0.02735127,0.0003120556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758644,0.004582406,0.00004568163,0.00604659,0.0003981954,0.0004333476,0.00004598373,0.0002147695,0.01236866],"genre_scores_gemma":[0.9907311,0.001436569,0.0000618847,0.0002067066,0.0006993276,0.00006946617,0.00002341289,0.00006623484,0.006705309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3766172,"threshold_uncertainty_score":0.9289172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0889990070505941,"score_gpt":0.3746807089794629,"score_spread":0.2856817019288688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}