{"id":"W4405614291","doi":"10.21203/rs.3.rs-5555692/v1","title":"KidneyGenAfrica: A multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 continental and diasporan Africans","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Lethbridge","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Department for International Development; Fogarty International Center; National Heart, Lung, and Blood Institute; London School of Hygiene and Tropical Medicine; Medical Research Council; American Heart Association; South African Medical Research Council; Deutsche Forschungsgemeinschaft; UK Research and Innovation; Government of the United Kingdom; National Institutes of Health","keywords":"Genome-wide association study; 1000 Genomes Project; Genetics; Genetic genealogy; Biology; Demography; Evolutionary biology; Population; Single-nucleotide polymorphism; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001111356,0.0006192385,0.0005948483,0.0009174813,0.001578916,0.001160095,0.0007190339,0.0008556173,0.002768931],"category_scores_gemma":[0.002290052,0.000529739,0.0007729849,0.00216081,0.0003858612,0.0005376524,0.001457269,0.0007583708,0.0004310596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003275081,"about_ca_system_score_gemma":0.0004564493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03304549,"about_ca_topic_score_gemma":0.02839735,"domain_scores_codex":[0.9993442,0.0002455316,0.00004157495,0.0002109012,0.00004645812,0.0001113454],"domain_scores_gemma":[0.9992068,0.000151382,0.0001630445,0.0002347803,0.00007080505,0.0001732347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006305862,0.00007521387,0.9942048,0.00001659437,0.0004764886,0.0002143466,0.0005034587,0.00006225051,0.001274717,0.0001337016,0.0007737389,0.001634215],"study_design_scores_gemma":[0.00005405644,0.00005432367,0.9979056,0.00001043297,0.0002147328,0.0002556853,0.0004565712,0.0001874159,0.0001093785,0.00006299109,0.0006812204,0.000007632575],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972129,0.00009478662,0.0001824431,0.0000887425,0.000009471916,0.0000109218,0.002140095,0.000008306727,0.0002522937],"genre_scores_gemma":[0.9970771,0.0001069811,0.0003814387,0.00005355792,0.00001845716,0.0000323337,0.001659784,0.00001524699,0.0006551771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03304549,"threshold_uncertainty_score":0.06570625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03203906183916322,"score_gpt":0.3292451128616702,"score_spread":0.297206051022507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}