{"id":"W4405614588","doi":"10.1172/jci.insight.181481","title":"MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Sahlgrenska Akademin; Uppsala Multidisciplinary Center for Advanced Computational Science; Stiftelsen Clas Groschinskys Minnesfond; Jeanssons Stiftelser; Göteborgs Universitet; Knut och Alice Wallenbergs Stiftelse; Svenska Sällskapet för Medicinsk Forskning; Sahlgrenska Universitetssjukhuset; Science for Life Laboratory; Västra Götalandsregionen; Vetenskapsrådet; National Institute of Allergy and Infectious Diseases; Stiftelserna Wilhelm och Martina Lundgrens; National Institutes of Health; Biocodex Microbiota Foundation; Wenner-Gren Stiftelserna; CH.I.L.D. Foundation; Åke Wiberg Stiftelse","keywords":"Mucin; Glycocalyx; Ileum; Biology; Immune system; Small intestine; Crohn's disease; Bacteria; Inflammation; Microbiology; Crypt; Cell biology; Immunology; Disease; Pathology; Medicine; Biochemistry; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009771956,0.0002785139,0.000158823,0.0001227008,0.00007356951,0.0001443876,0.0002849828,0.0001369781,0.0003317505],"category_scores_gemma":[0.00003961163,0.0002623634,0.0001638193,0.000128527,0.0001242962,0.00001742814,0.0001987513,0.000182692,0.0001363294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004850365,"about_ca_system_score_gemma":0.0002237616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004998412,"about_ca_topic_score_gemma":0.000146138,"domain_scores_codex":[0.9983946,0.00009591019,0.0002739383,0.0006719419,0.0002068066,0.0003568167],"domain_scores_gemma":[0.9989517,0.00001200226,0.00004654003,0.0005699915,0.00005897835,0.0003607852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00787266,0.00377747,0.2832765,0.00206939,0.0007852174,0.05441085,0.006748152,0.0002453435,0.5686739,0.003295569,0.05140135,0.01744356],"study_design_scores_gemma":[0.001360534,0.0001425429,0.8583776,0.0002632278,0.0001652629,0.00004047529,0.0001339202,0.007943976,0.05374272,0.0004337204,0.07644705,0.0009489799],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963227,0.0009467684,0.0004004656,0.0004125286,0.0004409497,0.0002846172,0.0001213657,0.00006608375,0.001004557],"genre_scores_gemma":[0.9969938,0.00004655879,0.0001596637,0.001178355,0.0003989949,0.00005543683,0.0003842105,0.00005243894,0.0007305863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5751011,"threshold_uncertainty_score":0.9999828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857145559705347,"score_gpt":0.2617431264619662,"score_spread":0.2431716708649127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}