{"id":"W4405614588","doi":"10.1172/jci.insight.181481","title":"MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohn’s disease","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Sahlgrenska Akademin; Uppsala Multidisciplinary Center for Advanced Computational Science; Stiftelsen Clas Groschinskys Minnesfond; Jeanssons Stiftelser; Göteborgs Universitet; Knut och Alice Wallenbergs Stiftelse; Svenska Sällskapet för Medicinsk Forskning; Sahlgrenska Universitetssjukhuset; Science for Life Laboratory; Västra Götalandsregionen; Vetenskapsrådet; National Institute of Allergy and Infectious Diseases; Stiftelserna Wilhelm och Martina Lundgrens; National Institutes of Health; Biocodex Microbiota Foundation; Wenner-Gren Stiftelserna; CH.I.L.D. Foundation; Åke Wiberg Stiftelse","keywords":"Mucin; Glycocalyx; Ileum; Biology; Immune system; Small intestine; Crohn's disease; Bacteria; Inflammation; Microbiology; Crypt; Cell biology; Immunology; Disease; Pathology; Medicine; Biochemistry; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134761,0.0004452795,0.000276766,0.0004937354,0.0002025699,0.0003602121,0.0001617119,0.0003812052,0.001207888],"category_scores_gemma":[0.0001536307,0.0001640273,0.0001894186,0.0002472659,0.0004223627,0.0002038794,0.000371284,0.0005604193,0.0003237354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629092,"about_ca_system_score_gemma":0.0002638167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006209062,"about_ca_topic_score_gemma":0.0006881511,"domain_scores_codex":[0.9998995,0.0000137222,0.00001109349,0.00002098285,0.00002868943,0.00002599892],"domain_scores_gemma":[0.9998702,0.00001018636,0.00005479154,0.000008963165,0.00001138592,0.00004438145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002313551,0.00001183311,0.003223445,0.00007535565,0.00001100899,0.0007568829,0.00003118632,0.00005093929,0.9920092,0.0002104787,0.0001019976,0.003286499],"study_design_scores_gemma":[0.00005976135,0.0003317659,0.109489,0.00008296694,0.0001043714,0.01426346,0.0003095186,0.000883467,0.8564274,0.0005192287,0.0175077,0.00002143291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913059,0.004644931,0.001827879,0.0002660833,0.0000536167,0.00001117464,0.0006229613,0.0001052037,0.001162263],"genre_scores_gemma":[0.9953011,0.001724384,0.001481312,0.00006916006,0.00001020253,0.00000723558,0.0004069896,0.00002395548,0.0009756663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001207888,"threshold_uncertainty_score":0.004040778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01857145559705347,"score_gpt":0.2617431264619662,"score_spread":0.2431716708649127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}