{"id":"W4405616017","doi":"10.1172/jci.insight.178535","title":"YAP/TAZ mediates resistance to KRAS inhibitors through inhibiting proapoptosis and activating the SLC7A5/mTOR axis","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Future Earth","funders":"First Hospital of Jilin University; Department of Science and Technology of Jilin Province; Jilin University; People's Government of Jilin Province; National Natural Science Foundation of China; Jilin Province Development and Reform Commission","keywords":"KRAS; Hippo signaling pathway; Cancer research; PI3K/AKT/mTOR pathway; Dasatinib; Gene knockdown; Chemistry; Apoptosis; Cancer; Kinase; Signal transduction; Biology; Cell biology; Medicine; Internal medicine; Tyrosine kinase; Colorectal cancer; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008976626,0.0002806594,0.0001817031,0.0001967026,0.000180163,0.0002781299,0.0001586737,0.0001649239,0.001290216],"category_scores_gemma":[0.00004875534,0.0001021158,0.000221879,0.0001268469,0.0001985292,0.0001810172,0.0001592168,0.0004896431,0.0002392902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002804574,"about_ca_system_score_gemma":0.0002865977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005685556,"about_ca_topic_score_gemma":0.001437626,"domain_scores_codex":[0.9999262,0.000009617758,0.000005680975,0.00001100645,0.00002222972,0.0000252375],"domain_scores_gemma":[0.9999737,0.00000262992,0.000009074534,0.000002769095,0.000003623348,0.000008361655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000154121,0.00003990684,0.0005500234,0.00004781264,0.00001084645,0.0000899481,0.00001034376,0.0001248151,0.9946365,0.0003846586,0.0001717584,0.00377923],"study_design_scores_gemma":[0.00004399351,0.0004556923,0.01193264,0.000006476604,0.00003095844,0.000484113,0.00004477315,0.002011684,0.9784378,0.0001435634,0.006403229,0.000005126162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917496,0.002434715,0.002158671,0.0003833718,0.00003145358,0.00002259638,0.0003192351,0.0001264924,0.00277382],"genre_scores_gemma":[0.9962199,0.001297596,0.0006770548,0.0000471033,0.000007170518,0.00001730896,0.0002396905,0.00000798813,0.001486321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001290216,"threshold_uncertainty_score":0.004316151,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396969584753253,"score_gpt":0.2522406139457612,"score_spread":0.2382709180982287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}