{"id":"W4405618609","doi":"10.1016/j.biologicals.2024.101778","title":"Integrating 3Rs approaches in WHO guidelines for the batch release testing of biologicals: Summary of NC3Rs final report to WHO Expert Committee for Biological Standardisation","year":2024,"lang":"en","type":"article","venue":"Biologicals","topic":"Respiratory viral infections research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Centre for the Replacement Refinement and Reduction of Animals in Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Bill and Melinda Gates Foundation","keywords":"Biochemical engineering; Computer science; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1650857,0.002638616,0.002255876,0.008988873,0.002468292,0.008369987,0.01077879,0.01665577,0.007017628],"category_scores_gemma":[0.1134535,0.00269521,0.005324896,0.005221869,0.005512826,0.003956009,0.00476556,0.01216741,0.01076087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009263749,"about_ca_system_score_gemma":0.06711176,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05730133,"about_ca_topic_score_gemma":0.04483287,"domain_scores_codex":[0.845507,0.04205552,0.02211993,0.004765372,0.07915395,0.006398096],"domain_scores_gemma":[0.7594888,0.04212818,0.01827868,0.01045672,0.1657359,0.003911922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002911071,0.00052742,0.002520123,0.00852883,0.0001089876,0.001119077,0.002726989,0.002422303,0.01426487,0.02351899,0.7990535,0.1449179],"study_design_scores_gemma":[0.00003923264,0.0002484512,0.002823656,0.004433288,0.00008593952,0.0002688466,0.0005355153,0.0002954767,0.004051071,0.002745215,0.9843531,0.0001201569],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.01050365,0.09180917,0.2169104,0.2710029,0.03642998,0.04241201,0.03829316,0.006678292,0.2859604],"genre_scores_gemma":[0.03167184,0.0991198,0.4264074,0.1425869,0.007879382,0.03748249,0.05087384,0.002960193,0.2010181],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1650857,"threshold_uncertainty_score":0.8730671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.620108000662358,"score_gpt":0.5044749024143836,"score_spread":0.1156330982479744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}