{"id":"W4405618609","doi":"10.1016/j.biologicals.2024.101778","title":"Integrating 3Rs approaches in WHO guidelines for the batch release testing of biologicals: Summary of NC3Rs final report to WHO Expert Committee for Biological Standardisation","year":2024,"lang":"en","type":"article","venue":"Biologicals","topic":"Respiratory viral infections research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"National Centre for the Replacement Refinement and Reduction of Animals in Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Bill and Melinda Gates Foundation","keywords":"Biochemical engineering; Computer science; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.004465269,0.0002285868,0.0007327994,0.0002079943,0.000118242,0.00003218725,0.0002356106,0.0002969686,0.0000321436],"category_scores_gemma":[0.0436278,0.0001089973,0.0002665788,0.0007350513,0.0003684871,0.0000570653,0.0001447808,0.0002628742,0.000001498935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001066701,"about_ca_system_score_gemma":0.0001728456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001083528,"about_ca_topic_score_gemma":0.00001242239,"domain_scores_codex":[0.9972631,0.0002726596,0.001327744,0.0005554183,0.000217304,0.0003638067],"domain_scores_gemma":[0.9934351,0.005118766,0.0002047758,0.0003795344,0.0007675524,0.00009422572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002873095,0.0006136089,0.189283,0.0008904311,0.0003113432,0.00007826142,0.0004663048,0.0007217923,0.2758626,0.006018638,0.03699135,0.4858896],"study_design_scores_gemma":[0.00604225,0.03977052,0.2180072,0.008609199,0.0003010377,0.0003889415,0.01099852,0.09896608,0.1620473,0.01367567,0.4391993,0.001994034],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.948046,0.004990359,0.03690265,0.005351225,0.0001477886,0.003641247,0.0002050903,0.00011462,0.000600991],"genre_scores_gemma":[0.9642587,0.0002447105,0.03283431,0.000581857,0.0003766971,0.001357929,0.00009356013,0.0000211242,0.0002310735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4838956,"threshold_uncertainty_score":0.9644281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.620108000662358,"score_gpt":0.5044749024143836,"score_spread":0.1156330982479744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}