{"id":"W4405622922","doi":"10.1371/journal.pone.0305440","title":"Effects of lysine and methionine on mRNA expression of candidate transcription factors by primary bovine mammary epithelial cells","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Endoplasmic reticulum; Methionine; EGR1; Transcription factor; ATF6; ATF4; Gene expression; Amino acid; Unfolded protein response; Molecular biology; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003301628,0.0003541,0.0006341626,0.000268648,0.0002544197,0.000356714,0.0002037249,0.0002308936,0.001055622],"category_scores_gemma":[0.0001366175,0.0001846924,0.0004203111,0.0002581787,0.0001845479,0.0001746492,0.0002438668,0.0004677082,0.0004080638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004908675,"about_ca_system_score_gemma":0.0003261095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002720781,"about_ca_topic_score_gemma":0.004975077,"domain_scores_codex":[0.9996461,0.00006052933,0.00004914096,0.00008675305,0.00006640388,0.00009120239],"domain_scores_gemma":[0.9998233,0.00005036385,0.00003457907,0.00001845528,0.00003531489,0.00003804917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001812243,0.00001465056,0.0001093473,0.00003121248,0.000002131584,0.00001810064,0.00001668216,0.00001296534,0.9992759,0.00001268784,0.00001061076,0.0003145262],"study_design_scores_gemma":[0.00001541055,0.0005955208,0.005469264,0.000006822612,0.00001965005,0.00009569544,0.00006125063,0.000282388,0.9913046,0.00001507531,0.002128825,0.0000055112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847497,0.009517741,0.00239431,0.0001111337,0.00008201004,0.00004782399,0.001087366,0.00007674241,0.001933081],"genre_scores_gemma":[0.9862466,0.003095588,0.004260188,0.0001336368,0.00003005358,0.0001006448,0.002087082,0.00004019474,0.00400605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002720781,"threshold_uncertainty_score":0.005409896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008081590523446919,"score_gpt":0.2093769632746715,"score_spread":0.2012953727512245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}