{"id":"W4405622942","doi":"10.1093/ibd/izae269","title":"Eleven Grand Challenges for Inflammatory Bowel Disease Genetics and Genomics","year":2024,"lang":"en","type":"review","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Inflammatory bowel disease; Genomics; Inflammatory Bowel Diseases; Medicine; Disease; Genetics; Biology; Genome; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003054464,0.0008518432,0.001479205,0.00230807,0.0006934964,0.002502774,0.001184187,0.00250929,0.005436794],"category_scores_gemma":[0.003404889,0.0003170176,0.000765626,0.002347315,0.001593769,0.004108792,0.001830777,0.006328181,0.003049803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001358097,"about_ca_system_score_gemma":0.003721301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00144627,"about_ca_topic_score_gemma":0.002525958,"domain_scores_codex":[0.9992144,0.0002485248,0.00008838881,0.0000955638,0.000255016,0.00009802895],"domain_scores_gemma":[0.9975758,0.001360801,0.0001362505,0.00008435825,0.0005730106,0.0002697312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009694898,0.00007001004,0.0003344739,0.006271277,0.00008650628,0.0004100123,0.0001893185,0.0002621517,0.0008418605,0.02203079,0.1716611,0.7977455],"study_design_scores_gemma":[0.000009576494,0.00003735227,0.0003687908,0.002395931,0.00003286962,0.000698325,0.0001303125,0.00004890656,0.00007863588,0.007593249,0.9885903,0.0000157526],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000905983,0.9857755,0.0003151155,0.01082245,0.001671771,0.000003164668,0.0000213536,0.00002164982,0.001278435],"genre_scores_gemma":[0.0007908759,0.9892355,0.0007925041,0.005046264,0.002566035,0.000009572094,0.00005508796,0.00000766173,0.001496491],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005436794,"threshold_uncertainty_score":0.01818794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258357369256132,"score_gpt":0.2810568657243223,"score_spread":0.2584732920317609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}