{"id":"W4405628111","doi":"10.1248/bpb.b24-00567","title":"Cynaropicrin Increases [Ca&lt;sup&gt;2+&lt;/sup&gt;]&lt;sub&gt;i&lt;/sub&gt; and Ciliary Beat Frequency in Human Airway Epithelial Cells by Inhibiting SERCA","year":2024,"lang":"en","type":"article","venue":"Biological and Pharmaceutical Bulletin","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science","keywords":"SERCA; Endoplasmic reticulum; Biology; Cell biology; Cilium; Intracellular; Biophysics; Biochemistry; ATPase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009508918,0.0008207205,0.0008265738,0.0002252635,0.0006274107,0.0003056816,0.0004764617,0.0006851611,0.003234035],"category_scores_gemma":[0.0005359083,0.0005852114,0.0002608319,0.0005446027,0.001260549,0.0001553617,0.0006693415,0.001178654,0.0006255588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000993344,"about_ca_system_score_gemma":0.000055325,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004302214,"about_ca_topic_score_gemma":0.000007925525,"domain_scores_codex":[0.9941723,0.001051288,0.001017564,0.001842092,0.0005508149,0.001365933],"domain_scores_gemma":[0.9973252,0.001455973,0.0001213833,0.0002207644,0.00006200484,0.0008146702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001963516,0.0004721928,0.0003493017,0.0002082525,0.00001966138,0.0003836584,0.0001682842,0.00001281824,0.9792493,0.001643277,0.009631068,0.00766586],"study_design_scores_gemma":[0.00145324,0.0007686585,0.0002385112,0.0003193951,0.00005616685,0.0001398351,0.00005922211,0.001577256,0.7289903,0.001085708,0.2642806,0.001031023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854886,0.005943231,0.00004645075,0.004245917,0.0006419515,0.0007657913,0.0006278545,0.0002865132,0.001953684],"genre_scores_gemma":[0.9882198,0.007506172,0.0001012483,0.002309987,0.0009001394,0.00009120414,0.00007868693,0.00006116995,0.0007315745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2546496,"threshold_uncertainty_score":0.99966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816387724448237,"score_gpt":0.2867645209995641,"score_spread":0.2486006437550818,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}