{"id":"W4405632828","doi":"10.1126/sciadv.adp6660","title":"Molecular basis for plasma membrane recruitment of PI4KA by EFR3","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; British Columbia Knowledge Development Fund; National Institutes of Health; Michael Smith Health Research BC","keywords":"Heterotrimeric G protein; Cell biology; Phosphatidylinositol; Hydrogen–deuterium exchange; Biology; Chemistry; Membrane; Regulator; Biochemistry; Kinase; Signal transduction; Gene; G protein; Mass spectrometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002300292,0.00008001549,0.00008063795,0.00004469514,0.00005784761,0.00002064136,0.0001787098,0.000037767,0.0000103683],"category_scores_gemma":[0.00002819052,0.00006911131,0.00006998848,0.0001978992,0.0002427441,0.00001418807,0.00001754344,0.00002594045,0.000001906849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001006191,"about_ca_system_score_gemma":0.00008687048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000289211,"about_ca_topic_score_gemma":0.000006379308,"domain_scores_codex":[0.9991941,0.000006020638,0.0001280314,0.0003262077,0.0001719188,0.0001737079],"domain_scores_gemma":[0.9997091,0.00000959051,0.00002774623,0.0001520996,0.00005356914,0.0000478712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002334316,0.00001443761,0.00004941051,0.00006032291,0.00000768096,0.000001033131,0.00003155171,0.00008127197,0.9831807,0.0003913752,0.00002691596,0.01613193],"study_design_scores_gemma":[0.00008311062,0.0001494685,0.0000147668,0.00002296525,0.00001013294,0.000001291009,0.00004124883,0.0002717215,0.8068098,0.0001037732,0.1924185,0.00007321073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9538947,0.008541207,0.03593277,0.0001732206,0.0003617826,0.0003308131,0.00006380321,0.00001473821,0.000686985],"genre_scores_gemma":[0.997347,0.0004070094,0.001565645,0.00004123541,0.00003428641,0.00005350856,0.0002301786,0.000008369455,0.0003127832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1923916,"threshold_uncertainty_score":0.2818277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539782220864964,"score_gpt":0.2858977276971774,"score_spread":0.2704999054885277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}