{"id":"W4405632828","doi":"10.1126/sciadv.adp6660","title":"Molecular basis for plasma membrane recruitment of PI4KA by EFR3","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; British Columbia Knowledge Development Fund; National Institutes of Health; Michael Smith Health Research BC","keywords":"Heterotrimeric G protein; Cell biology; Phosphatidylinositol; Hydrogen–deuterium exchange; Biology; Chemistry; Membrane; Regulator; Biochemistry; Kinase; Signal transduction; Gene; G protein; Mass spectrometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008478451,0.0002271622,0.0001582737,0.00006591428,0.0003694656,0.000261752,0.0004119761,0.0005438381,0.001283478],"category_scores_gemma":[0.0001202253,0.0001307723,0.0002769806,0.00005818231,0.0002939555,0.0002257172,0.0002296345,0.0005283293,0.0007145814],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006514408,"about_ca_system_score_gemma":0.0002729032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001553524,"about_ca_topic_score_gemma":0.001028295,"domain_scores_codex":[0.9999474,0.000006182045,0.000003716481,0.00001338385,0.00001380689,0.00001548399],"domain_scores_gemma":[0.9999572,0.000006218554,0.00001174093,0.000005773925,0.00000559558,0.00001350888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002017803,0.000022501,0.0005197484,0.00003269542,0.000005510932,0.0005930333,0.0000206732,0.0006776992,0.9954919,0.001460401,0.0001582445,0.0008159062],"study_design_scores_gemma":[0.00009236872,0.0001037102,0.01188796,0.00001994499,0.00001392386,0.001308657,0.0001266934,0.0164809,0.9635398,0.001397468,0.005005554,0.00002313201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901335,0.0007082709,0.004918433,0.0006748585,0.00005518043,0.00001991763,0.0002261159,0.0001390176,0.003124634],"genre_scores_gemma":[0.9969734,0.0002647468,0.001368973,0.0001172577,0.000006234684,0.00001150607,0.0002099907,0.00001275504,0.001035126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001553524,"threshold_uncertainty_score":0.004726529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539782220864964,"score_gpt":0.2858977276971774,"score_spread":0.2704999054885277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}