{"id":"W4405635648","doi":"10.1016/j.nsa.2024.105351","title":"The negative allosteric modulator of GABAA receptor, L655,708, increased dopamine neuronal activity 24 hours but not immediately after injection","year":2024,"lang":"en","type":"article","venue":"Neuroscience Applied","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"GABAA receptor; Allosteric modulator; Allosteric regulation; Dopamine; Chemistry; Neuroscience; Pharmacology; Dopamine receptor; Receptor; Medicine; Psychology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001998592,0.0007093685,0.0008309488,0.0003455861,0.0003621966,0.0004998975,0.0004246244,0.00075532,0.005632596],"category_scores_gemma":[0.0003521395,0.0002965907,0.0005949166,0.0003351162,0.0008471597,0.0005338343,0.0002606883,0.001938681,0.0007915775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006843044,"about_ca_system_score_gemma":0.000915495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002255952,"about_ca_topic_score_gemma":0.00425744,"domain_scores_codex":[0.9996939,0.00003049367,0.00002109684,0.00005266634,0.0000366991,0.0001651465],"domain_scores_gemma":[0.9997392,0.00005796108,0.00004083987,0.00003086308,0.0000255196,0.0001055423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006922428,0.0008699333,0.0003430128,0.0001021383,0.00003436236,0.0002177886,0.00009528264,0.00011062,0.9856242,0.0002760863,0.0007357317,0.004668483],"study_design_scores_gemma":[0.0004202229,0.00647421,0.004332043,0.00001743708,0.00005568196,0.0001750159,0.0001461043,0.0008685815,0.9855583,0.0001302533,0.001799188,0.00002287309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946771,0.0005948038,0.0008063558,0.0004413164,0.0004366812,0.00005374427,0.0004738401,0.0001562584,0.002359895],"genre_scores_gemma":[0.990235,0.000503507,0.0009733178,0.0001717002,0.00008478946,0.0001122055,0.0005772274,0.00004420978,0.007298102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005632596,"threshold_uncertainty_score":0.01884294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0119463514995629,"score_gpt":0.2341302745101567,"score_spread":0.2221839230105938,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}