{"id":"W4405637511","doi":"10.1093/braincomms/fcae382","title":"Brain age in genetic and idiopathic Parkinson's disease","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"DoD Alzheimer's Disease Neuroimaging Initiative; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; Synarc; University of Southern California; Medpace; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Dementia; Disease; Cohort; Cognitive decline; Medicine; Asymptomatic; Neuroimaging; LRRK2; Alzheimer's disease; Internal medicine; Parkinson's disease; Psychology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002126947,0.0001393036,0.0001795019,0.0001890557,0.0001168055,0.00006638856,0.000201277,0.00005116159,0.00002954112],"category_scores_gemma":[0.0001947653,0.0001306203,0.000070113,0.0003019475,0.000120492,0.00006480073,0.0001902372,0.000201185,0.00006658871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007388528,"about_ca_system_score_gemma":0.0001679083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000536491,"about_ca_topic_score_gemma":0.0001775332,"domain_scores_codex":[0.9990349,0.0001544452,0.0002001322,0.0002833227,0.0001354275,0.0001917294],"domain_scores_gemma":[0.9982976,0.0002491277,0.00002314803,0.001141646,0.00001800502,0.0002704749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0004984979,0.004787505,0.2978593,0.002124472,0.0008601143,0.0108214,0.00507326,0.00003137373,0.00717541,0.1027808,0.02983901,0.5381488],"study_design_scores_gemma":[0.0008502647,0.00005966304,0.5794327,0.0005451731,0.0001111228,0.0000427851,0.00006372181,0.004494954,0.00001457191,0.005560619,0.4086779,0.0001465232],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7432636,0.1591371,0.0005098543,0.09114169,0.0001365388,0.001146086,0.0001143595,0.0003553451,0.004195462],"genre_scores_gemma":[0.9929289,0.002082578,0.002060951,0.001734485,0.00003505985,0.0002045411,0.00008610287,0.00003041075,0.000837037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5380023,"threshold_uncertainty_score":0.5326543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03285313093088187,"score_gpt":0.3119947904747549,"score_spread":0.279141659543873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}