{"id":"W4405637511","doi":"10.1093/braincomms/fcae382","title":"Brain age in genetic and idiopathic Parkinson's disease","year":2024,"lang":"en","type":"article","venue":"Brain Communications","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"DoD Alzheimer's Disease Neuroimaging Initiative; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; BioClinica; Synarc; University of Southern California; Medpace; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; National Institute on Aging; Alzheimer's Association","keywords":"Dementia; Disease; Cohort; Cognitive decline; Medicine; Asymptomatic; Neuroimaging; LRRK2; Alzheimer's disease; Internal medicine; Parkinson's disease; Psychology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00092014,0.000297821,0.0003137971,0.0007787651,0.0002826729,0.0003857307,0.000296464,0.0005157721,0.0006630727],"category_scores_gemma":[0.002592635,0.0002976975,0.0003060755,0.0004265714,0.0003372814,0.0004138588,0.000626017,0.000369413,0.00007809882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002936278,"about_ca_system_score_gemma":0.0002486757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004411841,"about_ca_topic_score_gemma":0.004899792,"domain_scores_codex":[0.999649,0.0001040607,0.00002725636,0.0001380554,0.0000530102,0.00002854512],"domain_scores_gemma":[0.9992419,0.0002155493,0.0003454873,0.00008190336,0.00004513946,0.00007002974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006566357,0.00004688,0.9935767,0.00001530135,0.0001103903,0.0003224021,0.0001847049,0.0003285807,0.001169721,0.0001439225,0.00006211556,0.003382712],"study_design_scores_gemma":[0.00001041494,0.0002111409,0.9973061,0.000006557621,0.00003634913,0.0008628227,0.00006256498,0.0008156084,0.00016026,0.0004012072,0.0001230926,0.00000400205],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993621,0.0002680416,0.0001631861,0.00001624092,0.000001449083,0.000001946391,0.00008632909,0.000002214219,0.00009867924],"genre_scores_gemma":[0.9995536,0.00008354672,0.0001393442,0.00001004325,0.000002297807,0.000003840174,0.0001214667,0.000001437649,0.00008435807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004411841,"threshold_uncertainty_score":0.008772314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03285313093088187,"score_gpt":0.3119947904747549,"score_spread":0.279141659543873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}