{"id":"W4405637695","doi":"10.1101/2024.12.19.629326","title":"The inhibitory effects of Remodelin on myoblasts differentiation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Deutsche Gesellschaft für Muskelkranke; Sigrid Juséliuksen Säätiö; Helsinki Institute of Life Science, Helsingin Yliopisto; Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; Samfundet Folkhälsan; Helsingin Yliopisto","keywords":"Myogenesis; C2C12; Cell biology; Myocyte; Biology; Cellular differentiation; MYF5; Lamin; MyoD; Transcriptome; Sarcomere; Myosin; Molecular biology; Gene expression; Genetics; Gene; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001853607,0.0003041165,0.0003106745,0.0001915856,0.0001485465,0.0003185791,0.0002315956,0.0002744704,0.002096575],"category_scores_gemma":[0.000214858,0.0001287214,0.0002709535,0.0001170055,0.0002005168,0.0001903387,0.0003410664,0.0006359487,0.0005290254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001987313,"about_ca_system_score_gemma":0.0002339296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007523667,"about_ca_topic_score_gemma":0.00106199,"domain_scores_codex":[0.9998034,0.00002465833,0.00002048889,0.00004554233,0.00006433207,0.00004159572],"domain_scores_gemma":[0.9998029,0.00005930067,0.00003135831,0.00002577647,0.0000331559,0.00004758385],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001287558,0.00001324593,0.0001339354,0.00003896502,0.000004832578,0.00003154144,0.00001517353,0.00003848781,0.9984134,0.00003377174,0.00003095315,0.001116801],"study_design_scores_gemma":[0.0000060025,0.0001478733,0.002335649,0.000003748139,0.0000101709,0.00005621037,0.00001481731,0.0001812919,0.9953684,0.0000111361,0.001861787,0.000002897818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901294,0.002895561,0.002089056,0.0001181049,0.00007564562,0.00002749715,0.0007361005,0.000120538,0.003808049],"genre_scores_gemma":[0.9855077,0.002147267,0.003291104,0.0001486519,0.00003328571,0.00006196176,0.001746789,0.00008275126,0.006980488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002096575,"threshold_uncertainty_score":0.007013679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004104043260884298,"score_gpt":0.1915435023323037,"score_spread":0.1874394590714194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}