{"id":"W4405637695","doi":"10.1101/2024.12.19.629326","title":"The inhibitory effects of Remodelin on myoblasts differentiation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"Deutsche Gesellschaft für Muskelkranke; Sigrid Juséliuksen Säätiö; Helsinki Institute of Life Science, Helsingin Yliopisto; Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; Samfundet Folkhälsan; Helsingin Yliopisto","keywords":"Myogenesis; C2C12; Cell biology; Myocyte; Biology; Cellular differentiation; MYF5; Lamin; MyoD; Transcriptome; Sarcomere; Myosin; Molecular biology; Gene expression; Genetics; Gene; Nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000190656,0.0003034591,0.0002164452,0.00008080382,0.0001042652,0.00007771595,0.0002497863,0.000482002,0.000002953531],"category_scores_gemma":[0.0001422369,0.0002397137,0.0001659552,0.0001074116,0.00007860275,0.000002353936,0.0004086883,0.0004624306,0.00002443865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004841259,"about_ca_system_score_gemma":0.0001535488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006240363,"about_ca_topic_score_gemma":0.0000029131,"domain_scores_codex":[0.9985812,0.00009501174,0.0002936992,0.0005728458,0.0002290741,0.0002281373],"domain_scores_gemma":[0.9986432,0.00003150193,0.0002068227,0.0008673489,0.0001802478,0.00007090547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007760341,0.00003190666,0.0001148045,0.0003810223,0.000140937,0.000003291194,0.000002956851,0.00006149606,0.9969226,0.0004985399,0.001747333,0.00001755741],"study_design_scores_gemma":[0.0002227419,0.0001874661,0.01146938,0.0003207647,0.0001010393,7.686744e-9,8.739236e-7,0.0002729719,0.98107,0.00002349495,0.00604913,0.0002821532],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934468,0.002198357,0.000419378,0.00009499705,0.003338031,0.0003861595,0.00003433662,0.00005918155,0.00002279083],"genre_scores_gemma":[0.9981779,0.0004256824,0.0001660189,0.00008851559,0.0009917059,0.00004565301,9.339706e-7,0.00008279629,0.00002073046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01585257,"threshold_uncertainty_score":0.9775241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004104043260884298,"score_gpt":0.1915435023323037,"score_spread":0.1874394590714194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}