{"id":"W4405638461","doi":"10.1016/j.medj.2024.11.013","title":"Molecular insights into trauma: A framework of epigenetic pathways to resilience through intervention","year":2024,"lang":"en","type":"review","venue":"Med","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital","funders":"National Institute on Minority Health and Health Disparities; National Institute of General Medical Sciences","keywords":"Biopsychosocial model; Psychological resilience; Psychological intervention; Adaptation (eye); Intervention (counseling); Psychology; Epigenetics; Dynamism; Maladaptation; Thriving; Medicine; Psychotherapist; Neuroscience; Biology; Psychiatry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002230384,0.0003749609,0.0007639815,0.0001420826,0.00003823978,0.00003125135,0.0004068081,0.000569183,0.00001136378],"category_scores_gemma":[0.0002805062,0.0003125479,0.0005873266,0.0004187047,0.0000665622,0.00000255939,0.0002523284,0.0002397873,0.00005080797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003864298,"about_ca_system_score_gemma":0.0001201188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002199821,"about_ca_topic_score_gemma":0.00002347624,"domain_scores_codex":[0.9978665,0.0002260153,0.0007338195,0.0006905182,0.0002537002,0.000229483],"domain_scores_gemma":[0.9988112,0.00003070952,0.0002414606,0.0007189736,0.00009905502,0.0000985359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001372143,0.0001030412,0.000001255056,0.009326986,0.0002203823,0.00001723586,0.0005600508,0.00004392288,0.01669951,0.0008898095,0.0001176118,0.9720065],"study_design_scores_gemma":[0.00009154223,0.0005017871,0.000004181287,0.007429899,0.0004934937,0.000001957561,0.00002909615,0.000005985641,0.08050892,0.006206624,0.9043263,0.0004002117],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005671528,0.953759,0.03912109,0.00001533946,0.0004403395,0.0006439716,0.00001672498,0.00001478965,0.0003172119],"genre_scores_gemma":[0.02171326,0.9733338,0.004197441,0.00002690856,0.0001724776,0.0001630061,0.0002080194,0.00007540014,0.0001096522],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9716063,"threshold_uncertainty_score":0.9999326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03027183763290928,"score_gpt":0.3493706087158966,"score_spread":0.3190987710829873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}