{"id":"W4405638499","doi":"10.1016/j.molcel.2024.11.033","title":"Mutability and hypermutation antagonize immunoglobulin codon optimality","year":2024,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Centers for Disease Control and Prevention; National Cancer Institute; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Somatic hypermutation; Biology; Genetics; Antibody; Computational biology; B cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003892009,0.0001362184,0.0001965257,0.00006909329,0.00004191582,0.00007213957,0.00006583014,0.0001035856,0.0001663493],"category_scores_gemma":[0.00009018761,0.0001205616,0.00008597545,0.0002233522,0.0001362904,0.00006125024,0.00008912159,0.0002237342,0.0001531272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002208495,"about_ca_system_score_gemma":0.001522003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003441066,"about_ca_topic_score_gemma":0.000001807688,"domain_scores_codex":[0.9986911,0.00007336585,0.000208583,0.0004139014,0.0003456626,0.0002673175],"domain_scores_gemma":[0.9993198,0.00008438526,0.00001711914,0.0003731479,0.00006671721,0.0001388246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003943468,0.0003277383,0.001306262,0.003534463,0.0001786252,0.006362661,0.00105898,0.000123839,0.9587235,0.0008420521,0.0007952192,0.02635231],"study_design_scores_gemma":[0.0127652,0.0005714969,0.005759272,0.0003170414,0.0003641994,0.001381737,0.0002544505,0.1337087,0.8194831,0.0008797857,0.02396277,0.0005522934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813771,0.005879554,0.002220047,0.0004946826,0.000104897,0.0004121451,0.00001024788,0.0001225637,0.00937874],"genre_scores_gemma":[0.9974388,0.0001285818,0.00147371,0.0001692031,0.00004363923,0.0000166913,0.00004813132,0.00003013312,0.0006511026],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1392404,"threshold_uncertainty_score":0.5775137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00868993809292268,"score_gpt":0.2875765666368656,"score_spread":0.278886628543943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}