{"id":"W4405640132","doi":"10.3390/curroncol31120594","title":"Targeting TOP2A in Ovarian Cancer: Biological and Clinical Implications","year":2024,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Ovarian cancer; Medicine; Cancer research; Cancer; Targeted therapy; Bioinformatics; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004134573,0.0002733782,0.0008575491,0.00008248806,0.00003910224,0.00001984757,0.0002175981,0.0006759744,0.00002711086],"category_scores_gemma":[0.00004906818,0.0002099882,0.0002622145,0.0001349165,0.0001086435,0.000001118769,0.0003078853,0.000518323,0.00001752347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009913207,"about_ca_system_score_gemma":0.0005409921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007590254,"about_ca_topic_score_gemma":0.00005711818,"domain_scores_codex":[0.998113,0.0002232039,0.0006420945,0.0006944672,0.00003948047,0.0002877793],"domain_scores_gemma":[0.9993912,0.00004990702,0.0001780215,0.0002438029,0.00003410475,0.0001029584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007157269,0.0000970507,0.0001065908,0.0006475442,0.00009632368,0.000003052844,0.000007019253,9.140731e-8,0.00008161252,0.0006777981,0.001150722,0.997125],"study_design_scores_gemma":[0.0002116116,0.0002563215,0.00002246628,0.0006547468,0.0003204652,0.0000221425,0.000005745275,0.000004454739,0.000003151939,0.0003694252,0.9978985,0.0002309663],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009094198,0.9965034,0.0001776847,0.0002288273,0.002232711,0.0004871831,0.0001324175,0.000008682757,0.000138117],"genre_scores_gemma":[0.0001425315,0.9976689,0.0001242077,0.00006771985,0.001175755,0.0003205525,0.0004086453,0.00003053417,0.00006117845],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9968941,"threshold_uncertainty_score":0.8563071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3025258952859203,"score_gpt":0.5412082537824726,"score_spread":0.2386823584965523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}