{"id":"W4405640132","doi":"10.3390/curroncol31120594","title":"Targeting TOP2A in Ovarian Cancer: Biological and Clinical Implications","year":2024,"lang":"en","type":"review","venue":"Current Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Ovarian cancer; Medicine; Cancer research; Cancer; Targeted therapy; Bioinformatics; Biology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003428112,0.0006657324,0.0008827914,0.001501544,0.0002475109,0.0007807907,0.0005586823,0.0007575578,0.003758027],"category_scores_gemma":[0.0004083924,0.0001942167,0.0004043595,0.001530844,0.0002470889,0.0009738954,0.0005335385,0.001560544,0.002277203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005053369,"about_ca_system_score_gemma":0.000788083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007309706,"about_ca_topic_score_gemma":0.001473465,"domain_scores_codex":[0.9999148,0.00001373887,0.00001036673,0.00001386293,0.00003564693,0.00001163728],"domain_scores_gemma":[0.9998651,0.00005231456,0.00001827064,0.000004055547,0.00004114519,0.00001921849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009577261,0.00006863705,0.0001413071,0.01677336,0.00008946549,0.0002361295,0.00004550477,0.0003622058,0.002821439,0.002703335,0.04024125,0.9364216],"study_design_scores_gemma":[0.0000210569,0.000114625,0.0006551411,0.002684794,0.0001317175,0.001264036,0.00003992553,0.0000796621,0.0006309296,0.001397341,0.9929676,0.00001318996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000127619,0.998392,0.00009152536,0.0003050089,0.0001888971,0.000004470613,0.00002134503,0.000007673409,0.0008613586],"genre_scores_gemma":[0.0004609652,0.9986492,0.0001085414,0.0001532468,0.0001089306,0.000004781538,0.00002943971,0.000001116358,0.0004837482],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003758027,"threshold_uncertainty_score":0.01257181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3025258952859203,"score_gpt":0.5412082537824726,"score_spread":0.2386823584965523,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}