{"id":"W4405640528","doi":"10.1158/2159-8290.cd-24-1366","title":"Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma","year":2024,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Ludwig Center at Harvard; Gray Foundation; Prairie Improvement Network; U.S. Department of Defense; Division of Cancer Prevention, National Cancer Institute; Honorable Tina Brozman Foundation; Canary Foundation; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","keywords":"Immune system; Serous fluid; Cancer research; Biology; Tumor microenvironment; Fallopian tube; Carcinogenesis; Ovarian carcinoma; Ovarian cancer; Cancer; Immunology; Pathology; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001469464,0.0003054252,0.0004634197,0.0001774779,0.00007058971,0.0001242928,0.00007826413,0.0001171894,0.00005714332],"category_scores_gemma":[0.00001443319,0.000255737,0.00009755231,0.0001835252,0.00003758377,0.0002560083,0.0001226482,0.0002577248,0.000009568064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008515933,"about_ca_system_score_gemma":0.0001957875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005993471,"about_ca_topic_score_gemma":0.0004683296,"domain_scores_codex":[0.9980496,0.00005215919,0.0004244718,0.0007774414,0.0002627622,0.0004335402],"domain_scores_gemma":[0.9993293,0.00005145796,0.00004820746,0.0003589468,0.0000153945,0.0001966572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001763396,0.0009616094,0.6981401,0.002281576,0.0005437499,0.001220225,0.005305683,0.008637588,0.214123,0.0009457426,0.0009272977,0.06514999],"study_design_scores_gemma":[0.004590653,0.0004783785,0.9002604,0.005231708,0.0004049785,0.00005866406,0.0003380972,0.008352373,0.0776193,0.0002152387,0.001852948,0.0005972362],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980642,0.01114785,0.0005863056,0.005196468,0.0008605666,0.00127921,0.0001665456,0.00004882798,0.00007229042],"genre_scores_gemma":[0.9949444,0.00128991,0.001908933,0.0003241001,0.000413639,0.0004326967,0.00008404512,0.00006555651,0.0005367552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2021203,"threshold_uncertainty_score":0.9999895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399184001921556,"score_gpt":0.2704764931128547,"score_spread":0.2564846530936391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}