{"id":"W4405648027","doi":"10.1186/s10020-024-01046-9","title":"Metabolomic signature of pediatric diabetic ketoacidosis: key metabolites, pathways, and panels linked to clinical variables","year":2024,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Children’s Health Research Institute; Hospital for Sick Children; Western University","funders":"London Health Sciences Foundation; Academic Medical Organization of Southwestern Ontario","keywords":"Diabetic ketoacidosis; Metabolomics; Medicine; Diabetes mellitus; Metabolite; Type 1 diabetes; Ketoacidosis; Insulin; Metabolic acidosis; Internal medicine; Endocrinology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003797647,0.0003940678,0.0004251229,0.0009481492,0.0001756092,0.0005259274,0.0001698865,0.0002316831,0.0005960575],"category_scores_gemma":[0.0007309727,0.00010259,0.0003150883,0.001198485,0.0001549577,0.0001788272,0.0003153335,0.0002379361,0.00009532424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002515288,"about_ca_system_score_gemma":0.000243087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008934805,"about_ca_topic_score_gemma":0.001153428,"domain_scores_codex":[0.9998026,0.0000409669,0.00002112185,0.00005969535,0.00004204806,0.00003357438],"domain_scores_gemma":[0.9995607,0.00006553027,0.0002311715,0.00002373231,0.00005681804,0.00006208366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008454141,0.00006864728,0.957405,0.00009760496,0.0001818853,0.0006653373,0.0000773657,0.0004533915,0.02764,0.00008110548,0.000209791,0.01227447],"study_design_scores_gemma":[0.00001111624,0.0002229175,0.9899039,0.00002129774,0.0001387332,0.001695551,0.0001140381,0.001332862,0.005801316,0.0001554542,0.0005957224,0.000007157837],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958448,0.001365156,0.001049355,0.00006077556,0.000006937634,0.00001952049,0.001301033,0.00002052734,0.0003318738],"genre_scores_gemma":[0.9965031,0.000515646,0.001883519,0.00003954123,0.000007377336,0.00001826797,0.0009483793,0.00000659182,0.00007761106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009481492,"threshold_uncertainty_score":0.002008438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179813552337264,"score_gpt":0.2659630972862752,"score_spread":0.2541649617629025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}