{"id":"W4405652424","doi":"10.1111/febs.17361","title":"Transfer <scp>RNA</scp> and small molecule therapeutics for aminoacyl‐<scp>tRNA</scp> synthetase diseases","year":2024,"lang":"en","type":"review","venue":"FEBS Journal","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aminoacyl tRNA synthetase; Transfer RNA; Genetic code; Amino acid; Biology; Translation (biology); Nucleic acid; RNA; Biochemistry; Amino Acyl-tRNA Synthetases; Protein biosynthesis; Aminoacylation; Small molecule; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005793009,0.0009258912,0.00134909,0.000228185,0.0003456081,0.000466247,0.0006947627,0.0008111835,0.00001179933],"category_scores_gemma":[0.0003644575,0.0006975141,0.001434797,0.0001603295,0.0001349178,0.00001481401,0.0001490627,0.0006335965,0.00003759976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004583615,"about_ca_system_score_gemma":0.0004735808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001773336,"about_ca_topic_score_gemma":0.000003216592,"domain_scores_codex":[0.9967654,0.0003761616,0.0008761174,0.0008516539,0.0003265146,0.0008040926],"domain_scores_gemma":[0.9981232,0.0003590056,0.0002977367,0.0005756581,0.0001554888,0.0004889448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002327742,0.0002503704,0.000003524385,0.01097209,0.003227009,0.0002416365,0.0001275686,0.000002978183,0.02475156,0.0004538291,0.00932801,0.9506181],"study_design_scores_gemma":[0.00038423,0.0004753642,9.723826e-7,0.002857813,0.004341398,0.0008936661,0.00007963223,0.000008057445,0.01728087,0.0006241166,0.9728446,0.0002092758],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001536095,0.9873856,0.007837152,0.00003963256,0.0008358597,0.001074996,0.0007888132,0.00003589112,0.0004659785],"genre_scores_gemma":[0.0002868081,0.9919459,0.00087032,0.0002871133,0.001743916,0.0002637238,0.0002675735,0.0002666414,0.004067957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9635166,"threshold_uncertainty_score":0.9995476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04203247328734045,"score_gpt":0.2973195083830445,"score_spread":0.2552870350957041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}