{"id":"W4405652424","doi":"10.1111/febs.17361","title":"Transfer <scp>RNA</scp> and small molecule therapeutics for aminoacyl‐<scp>tRNA</scp> synthetase diseases","year":2024,"lang":"en","type":"review","venue":"FEBS Journal","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aminoacyl tRNA synthetase; Transfer RNA; Genetic code; Amino acid; Biology; Translation (biology); Nucleic acid; RNA; Biochemistry; Amino Acyl-tRNA Synthetases; Protein biosynthesis; Aminoacylation; Small molecule; Gene; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003697731,0.0008578095,0.001017982,0.001936784,0.0002395286,0.0007628266,0.0007159731,0.001049939,0.005632762],"category_scores_gemma":[0.0004568847,0.000247367,0.0004537972,0.001481617,0.0002628448,0.0009696281,0.0006228574,0.001829155,0.004995878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004934168,"about_ca_system_score_gemma":0.0005728111,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004727882,"about_ca_topic_score_gemma":0.001025765,"domain_scores_codex":[0.9998757,0.00001654727,0.00001420878,0.00001795833,0.00005922722,0.00001642721],"domain_scores_gemma":[0.9998428,0.00005660538,0.00002623435,0.000005984501,0.00004226411,0.00002606261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001054052,0.00009910227,0.00008311587,0.01398108,0.00008599183,0.0002377158,0.00003568032,0.0003646294,0.005245253,0.003609874,0.05439024,0.9217619],"study_design_scores_gemma":[0.00001750108,0.00007874754,0.0003028318,0.001362283,0.00005978726,0.0007348806,0.00001643322,0.00006504612,0.0007524007,0.0009444957,0.9956561,0.00000964932],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002456764,0.995708,0.0002848927,0.0003207343,0.0005626919,0.0000151829,0.00005297169,0.00002965726,0.002780199],"genre_scores_gemma":[0.000937623,0.9957227,0.0003321117,0.0002982449,0.0001984829,0.00001779931,0.00009446732,0.000004873455,0.002393723],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005632762,"threshold_uncertainty_score":0.01884347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04203247328734045,"score_gpt":0.2973195083830445,"score_spread":0.2552870350957041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}