{"id":"W4405654993","doi":"10.1002/pbc.31487","title":"A Unique Case of a Pediatric Patient with Six Childhood Cancers in Association with a Germline <i>TP53</i> Gene Pathogenic Variant","year":2024,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; SickKids Foundation; University of Toronto; Hospital for Sick Children; University of Ottawa","funders":"","keywords":"Germline; Medicine; Gene; Association (psychology); Genetics; Blood cancer; Germline mutation; Oncology; Internal medicine; Cancer; Mutation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003842305,0.001220885,0.0009186351,0.001312079,0.002148591,0.00116108,0.001021843,0.005292044,0.003781134],"category_scores_gemma":[0.003407287,0.0007291856,0.0007781252,0.001095439,0.001262867,0.001294043,0.0009748956,0.004844419,0.0009348223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001352466,"about_ca_system_score_gemma":0.001046799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003270232,"about_ca_topic_score_gemma":0.004668804,"domain_scores_codex":[0.9994106,0.00009266742,0.00004640436,0.0001867298,0.00008287498,0.0001807056],"domain_scores_gemma":[0.9978915,0.0009762329,0.0003150729,0.0001188518,0.0001569092,0.0005414589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00002058932,0.0000160623,0.004821243,0.00001336979,0.000004926365,0.990862,0.0001375616,0.00007242506,0.0003436072,0.0003925926,0.002461772,0.0008538627],"study_design_scores_gemma":[0.00001014168,0.00003273568,0.003307656,0.00001453882,0.00001100204,0.9933301,0.0001305147,0.0001981863,0.0002019659,0.0003293706,0.00242624,0.000007476322],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8472491,0.00466969,0.006545341,0.07090864,0.003992149,0.0002307295,0.001136259,0.0004468286,0.06482142],"genre_scores_gemma":[0.9740486,0.001614761,0.003669285,0.009922789,0.003550146,0.00003884619,0.0002145525,0.00007744475,0.006863588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005292044,"threshold_uncertainty_score":0.01264918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005094171655889547,"score_gpt":0.2122944841253878,"score_spread":0.2072003124694983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}