{"id":"W4405658317","doi":"10.1016/j.jconrel.2024.12.021","title":"A preclinical design approach for translation of biohybrid photosensitive nanoplatform for photodynamic therapy of breast cancer","year":2024,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Photodynamic Therapy Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute for Medical Research Development; Mashhad University of Medical Sciences","keywords":"Photodynamic therapy; Photosensitizer; Nanotechnology; In vivo; Microfluidics; In silico; Computer science; Materials science; Chemistry; Biotechnology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003551602,0.0003247775,0.0001531642,0.0001405724,0.0002061481,0.000286704,0.0003273467,0.0004503862,0.001321584],"category_scores_gemma":[0.0002122801,0.0001991282,0.0003141036,0.00008554205,0.0002239107,0.0002745633,0.0002018417,0.0005978385,0.000385773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004814539,"about_ca_system_score_gemma":0.0004646334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008335313,"about_ca_topic_score_gemma":0.001370626,"domain_scores_codex":[0.9998784,0.00001629805,0.000009419373,0.0000341987,0.0000385458,0.00002313475],"domain_scores_gemma":[0.9999043,0.00001873565,0.00002592242,0.00001278722,0.00002567496,0.0000127036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002339159,0.00003240157,0.00001717153,0.00002933985,0.000002518421,0.00002177173,0.00001116046,0.0001853227,0.998077,0.0002556946,0.00004588682,0.001298188],"study_design_scores_gemma":[0.00001282965,0.000344832,0.0001584916,0.000003203228,0.0000102852,0.00006488163,0.000009362617,0.0009001992,0.9954854,0.00004868812,0.002957535,0.000004194676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8143098,0.001769273,0.1722469,0.0006444076,0.0003078614,0.001391259,0.0008825715,0.0005697871,0.007878178],"genre_scores_gemma":[0.9126812,0.001261313,0.07646779,0.0002611642,0.0000288429,0.0005720005,0.000624892,0.00006555833,0.008037318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321584,"threshold_uncertainty_score":0.004421115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0492767815663725,"score_gpt":0.3697561229384943,"score_spread":0.3204793413721218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}