{"id":"W4405659418","doi":"10.1093/brain/awae409","title":"De-escalating and discontinuing disease-modifying therapies in multiple sclerosis","year":2024,"lang":"en","type":"review","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Cilag; Instituto de Salud Carlos III; Janssen Pharmaceuticals; Sanofi Genzyme; Chugai Pharmaceutical; Novartis Pharma; Strategic Research Council; EMD Serono; MedDay Pharmaceuticals; Tays; University College London Hospitals NHS Foundation Trust; Deutsche Forschungsgemeinschaft; Bayer HealthCare; Multiple Sclerosis Society; National Institute for Health and Care Research; Galápagos; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; Argenx; Celltrion; Shionogi; Merck KGaA; Kiniksa Pharmaceuticals; National Institutes of Health; Mylan; H. Lundbeck A/S; Horizon Therapeutics; Monash University; Sanofi; TG Therapeutics; Genentech; European Commission; Fondation Brain Canada; European Committee for Treatment and Research in Multiple Sclerosis; Bundesministerium für Bildung und Forschung; Max-Planck-Gesellschaft; Atara Biotherapeutics; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu; Biogen; Agence Nationale de la Recherche; F. Hoffmann-La Roche; Alexion Pharmaceuticals; Bristol-Myers Squibb; Teva Pharmaceutical Industries; Eli Lilly and Company; U.S. Department of Defense; Multiple Sclerosis International Federation; Celgene; Moderna; International Progressive MS Alliance; National Multiple Sclerosis Society; Istanbul Üniversitesi-Cerrahpasa; GlaxoSmithKline; Patient-Centered Outcomes Research Institute; Amgen","keywords":"Multiple sclerosis; Medicine; Disease; Intensive care medicine; Modalities; Psychiatry; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001903298,0.0006996052,0.001794147,0.002420215,0.0002349366,0.001034007,0.001012552,0.001285799,0.003207312],"category_scores_gemma":[0.003515093,0.0002677459,0.001334181,0.00205799,0.0003503108,0.001040226,0.0006387621,0.001408647,0.0007090657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008253704,"about_ca_system_score_gemma":0.001559981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001386298,"about_ca_topic_score_gemma":0.003425071,"domain_scores_codex":[0.9992879,0.0002599785,0.0001837961,0.00006810639,0.0001612926,0.00003889811],"domain_scores_gemma":[0.9985455,0.0009777191,0.0002160289,0.00002686024,0.000200733,0.00003316683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001868476,0.0000498825,0.0001227339,0.106875,0.0004751596,0.0001320946,0.0000862004,0.0002442108,0.0005303772,0.001395095,0.01279908,0.8771032],"study_design_scores_gemma":[0.0001910552,0.0003586361,0.002386059,0.09967673,0.002493356,0.001792902,0.0001628204,0.0001924992,0.0006813107,0.00243755,0.8895825,0.00004472418],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005794207,0.9995258,0.00002660042,0.0001495884,0.00007122913,0.000005161608,0.000007928603,0.000002186901,0.0001535597],"genre_scores_gemma":[0.0006022101,0.9989482,0.0001023933,0.0001773139,0.00005690119,0.000008595515,0.00001389434,7.350805e-7,0.00008981871],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003207312,"threshold_uncertainty_score":0.01072955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2073639087695125,"score_gpt":0.3964255736704481,"score_spread":0.1890616649009356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}