{"id":"W4405663975","doi":"10.1016/j.omtn.2024.102442","title":"Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bioinformatics Solutions (Canada); Western University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Western University; Schulich School of Medicine and Dentistry; Huntington Society of Canada","keywords":"Missense mutation; Suppressor; Glutamine; Chemistry; Cell biology; Biology; Mutation; Biochemistry; Amino acid; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007909715,0.0003359975,0.0002323541,0.0001393663,0.00009821837,0.0002260396,0.00015777,0.0002603909,0.000943412],"category_scores_gemma":[0.0001020659,0.00006727933,0.0001749504,0.0001014844,0.0001288661,0.0000876296,0.0001101227,0.0004255301,0.0002500599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118364,"about_ca_system_score_gemma":0.0001941306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003741031,"about_ca_topic_score_gemma":0.0007177322,"domain_scores_codex":[0.9999424,0.000007446727,0.00000716932,0.00001162556,0.00001737596,0.0000140055],"domain_scores_gemma":[0.9999222,0.00002148124,0.00002013327,0.000008652204,0.00001076968,0.00001686525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302129,0.00007252558,0.0000884417,0.00002483667,0.000005443555,0.0000276408,0.000009876943,0.00008514648,0.9965168,0.00008520123,0.00007780784,0.002875943],"study_design_scores_gemma":[0.00003845229,0.001375211,0.002295378,0.000004640592,0.0000222722,0.000124488,0.00002352939,0.0007561051,0.9924694,0.00006240542,0.002823522,0.000004716355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927994,0.001813966,0.00213878,0.00009090546,0.00006753548,0.00004643966,0.0003459519,0.0002717295,0.002425263],"genre_scores_gemma":[0.9933531,0.001241106,0.001742548,0.00007395473,0.00001798895,0.00004748474,0.0006258364,0.00003426499,0.002863664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000943412,"threshold_uncertainty_score":0.003156066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009964462752732703,"score_gpt":0.2568469801517559,"score_spread":0.2468825173990232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}