{"id":"W4405671576","doi":"10.1111/epi.18197","title":"Factors associated with placebo response rate in randomized controlled trials of antiseizure medications for focal epilepsy","year":2024,"lang":"en","type":"article","venue":"Epilepsia","topic":"Epilepsy research and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Upsher-Smith; National Institutes of Health; Sunovion; Epilepsy Society; Eisai; GlaxoSmithKline; American Brain Foundation; Medical Center, University of Pittsburgh; University of Pittsburgh; Pfizer; American Academy of Neurology; American Epilepsy Society","keywords":"Placebo; Randomization; Medicine; Randomized controlled trial; Epilepsy; Adverse effect; Clinical trial; Concomitant; Internal medicine; Logistic regression; Anesthesia; Psychiatry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.454032,0.001559587,0.004984041,0.003338906,0.001185562,0.004113042,0.002037084,0.004323659,0.003101337],"category_scores_gemma":[0.5386249,0.001372121,0.01383337,0.005541933,0.003647829,0.003673018,0.002174327,0.004494851,0.0003738241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00152153,"about_ca_system_score_gemma":0.001816013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526066,"about_ca_topic_score_gemma":0.0005591036,"domain_scores_codex":[0.3101065,0.523623,0.1066028,0.02521516,0.03144881,0.003003726],"domain_scores_gemma":[0.1548362,0.6971701,0.1179447,0.02212386,0.006444179,0.001481084],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1367366,0.0007248171,0.5837552,0.02272876,0.1623171,0.0006636279,0.001424403,0.006662565,0.002645858,0.004614401,0.005788782,0.07193803],"study_design_scores_gemma":[0.02975657,0.01530125,0.7942914,0.005119068,0.08669145,0.001995307,0.0006428874,0.02970226,0.004940811,0.01511795,0.01597969,0.0004614608],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6372847,0.2052138,0.1177902,0.01332782,0.002981197,0.007225947,0.006510002,0.001148507,0.008517756],"genre_scores_gemma":[0.9788633,0.002252738,0.01227021,0.001706771,0.0004437212,0.003042273,0.0009936779,0.0001607951,0.0002664787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.545968,"threshold_uncertainty_score":0.6732758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06742309759907911,"score_gpt":0.3766629757487456,"score_spread":0.3092398781496665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}