{"id":"W4405673666","doi":"10.1101/2024.12.16.628794","title":"BACH2-driven tissue resident memory programs promote HIV-1 persistence","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Yale University","keywords":"Persistence (discontinuity); Human immunodeficiency virus (HIV); Computer science; Business; Psychology; Cognitive psychology; Biology; Virology; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001699917,0.0001716519,0.00014957,0.0001431074,0.0001863201,0.0004731249,0.00011459,0.0001486282,0.003176762],"category_scores_gemma":[0.0001333423,0.0001014183,0.0001716553,0.0001190384,0.0001939681,0.0002602502,0.0003145612,0.0003592909,0.000432057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002315226,"about_ca_system_score_gemma":0.000168541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000417742,"about_ca_topic_score_gemma":0.0006165407,"domain_scores_codex":[0.9998937,0.00001076371,0.00000430711,0.00002993667,0.00002122984,0.00004014334],"domain_scores_gemma":[0.9999323,0.000009763193,0.00001480164,0.000008522399,0.000009936035,0.00002470237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009362867,0.00000573293,0.002267953,0.00003256142,0.000004852592,0.00001985838,0.00002370561,0.0001232804,0.9949438,0.0001984493,0.0001347533,0.002151425],"study_design_scores_gemma":[0.00003124182,0.0002311027,0.06992067,0.00001702468,0.00002419487,0.0003208685,0.0001792891,0.00605085,0.9186794,0.0004805444,0.004053231,0.00001151282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925618,0.0009503797,0.003776812,0.0001010101,0.00002032052,0.00001085638,0.0007168426,0.0001234459,0.001738495],"genre_scores_gemma":[0.9968079,0.0001904684,0.000995558,0.00004236477,0.00001105126,0.000009564677,0.0004851159,0.00002064044,0.001437238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003176762,"threshold_uncertainty_score":0.01062727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116013680315946,"score_gpt":0.2434818026516879,"score_spread":0.2223216658485285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}