{"id":"W4405679183","doi":"10.1134/s0022093024060140","title":"The Calcium-Permeable AMPA Receptor Blocker IEM-1460 Increases the Intensity of Epileptiform Activity in the Entorhinal Cortex of Mice in vitro","year":2024,"lang":"en","type":"article","venue":"Journal of Evolutionary Biochemistry and Physiology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"AMPA receptor; Chemistry; Entorhinal cortex; In vitro; Intensity (physics); Calcium; Neuroscience; Calcium channel blocker; Receptor; Pharmacology; Biophysics; Hippocampus; Glutamate receptor; Medicine; Biology; Biochemistry; Physics; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849182,0.0006335431,0.0005556142,0.0004310475,0.0001233201,0.0002852573,0.0003632419,0.0004455483,0.001191004],"category_scores_gemma":[0.0001572726,0.0002839004,0.0003733647,0.0001586615,0.0002818497,0.0002765452,0.0002188624,0.00124108,0.0004230939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002945912,"about_ca_system_score_gemma":0.0001986388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008196017,"about_ca_topic_score_gemma":0.001252833,"domain_scores_codex":[0.9997763,0.00002757706,0.00003426539,0.00004688815,0.00005103815,0.00006391151],"domain_scores_gemma":[0.9997131,0.00002968699,0.00009589348,0.0000244605,0.00002568812,0.0001109756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001167546,0.00004069847,0.00007382054,0.00002332398,0.000006202878,0.00003212607,0.00001038113,0.00001529226,0.9993275,0.0000204995,0.00002205086,0.0003113829],"study_design_scores_gemma":[0.00003826728,0.0009765429,0.004024663,0.000009594292,0.00003172635,0.0001380335,0.00002688634,0.0005309024,0.993503,0.00002487396,0.0006908757,0.000004530376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935229,0.002132598,0.001932199,0.0001610271,0.00006051163,0.00004045069,0.000648746,0.0002564181,0.001245087],"genre_scores_gemma":[0.9921604,0.001454576,0.00188555,0.0001202713,0.00001944801,0.00009341163,0.0007148259,0.00006388608,0.003487689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191004,"threshold_uncertainty_score":0.003984272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02744326853451893,"score_gpt":0.3126412027955979,"score_spread":0.2851979342610789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}